Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset
Ina A. Stelzer(Palo Alto University), Mohammad Sajjad Ghaemi(Palo Alto University), Xiaoyuan Han(University of the Pacific), Kazuo Ando(Palo Alto University), Julien Hédou(Palo Alto University), Dorien Feyaerts(Palo Alto University), Laura S. Peterson(Stanford University), Kristen K. Rumer(Palo Alto University), Eileen S. Tsai(Palo Alto University), Edward A. Ganio(Palo Alto University), Dyani Gaudillière(Palo Alto University), Amy S. Tsai(Palo Alto University), Benjamin Choisy(Palo Alto University), L. Gaigne(Palo Alto University), Franck Verdonk(Palo Alto University), Danielle R. Jacobsen(Palo Alto University), Sonia Gavasso(Palo Alto University), Gavin M. Traber(Stanford University), Mathew Ellenberger(Stanford University), Natalie Stanley(Palo Alto University), Martin Becker(Palo Alto University), Anthony Culos(Palo Alto University), Ramin Fallahzadeh(Palo Alto University), Ronald J. Wong(Stanford University), Gary L. Darmstadt(Palo Alto University), Maurice L. Druzin(Palo Alto University), Virginia D. Winn(Palo Alto University), Ronald S. Gibbs(Palo Alto University), Xuefeng B. Ling(Palo Alto University), Karl G. Sylvester(Palo Alto University), Brendan Carvalho(Palo Alto University), M Snyder(Stanford University), Gary M. Shaw(Stanford University), David K. Stevenson(Stanford University), Kévin Contrepois(Stanford University), Martin S. Angst(Palo Alto University), Nima Aghaeepour(Palo Alto University), Brice Gaudillière(Palo Alto University)
Cited by 143Open Access
Abstract
= 10, independent test set]. Coordinated alterations in maternal metabolome, proteome, and immunome marked a molecular shift from pregnancy maintenance to prelabor biology 2 to 4 weeks before delivery. A surge in steroid hormone metabolites and interleukin-1 receptor type 4 that preceded labor coincided with a switch from immune activation to regulation of inflammatory responses. Our study lays the groundwork for developing blood-based methods for predicting the day of labor, anchored in mechanisms shared in preterm and term pregnancies.
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