Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Liam Gaziano; Claudia Giambartolomei; Alexandre C. Pereira; Anna Gaulton; Daniel Posner; Sonja A. Swanson; Yuk‐Lam Ho; Sudha K. Iyengar; Nicole Kosik; Marijana Vujković; David Gagnon; A. Patrícia Bento; Inigo Barrio‐Hernandez; Lars Rönnblom; Niklas Hagberg; Christian Lundtoft; Claudia Langenberg; Maik Pietzner; Dennis Valentine; Stefano Gustincich; Gian Gaetano Tartaglia; Elias Allara; Praveen Surendran; Stephen Burgess; Jing Hua Zhao; James E. Peters; Bram P. Prins; Emanuele Di Angelantonio; Poornima Devineni; Yunling Shi; Kristine E. Lynch; Scott L. DuVall; Helene Garcon; Lauren O. Thomann; Jin Zhou; Bryan R. Gorman; Jennifer E. Huffman; Christopher J. O’Donnell; Philip S. Tsao; Jean C. Beckham; Saiju Pyarajan; Sumitra Muralidhar; Grant D. Huang; Rachel Ramoni; Pedro Beltrão; John Danesh; Adriana M. Hung; Kyong‐Mi Chang; Yan V. Sun; Jacob Joseph; Andrew R. Leach; Todd L. Edwards; Kelly Cho; J. Michael Gaziano; Adam S. Butterworth; Juan P. Casas; VA Million Veteran Program COVID-19 Science Initiative

doi:10.1038/s41591-021-01310-z

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

Liam Gaziano(University of Cambridge), Claudia Giambartolomei(University of California, Los Angeles), Alexandre C. Pereira(Harvard University), Anna Gaulton(European Bioinformatics Institute), Daniel Posner(VA Boston Healthcare System), Sonja A. Swanson(Erasmus MC), Yuk‐Lam Ho(VA Boston Healthcare System), Sudha K. Iyengar(Louis Stokes Cleveland VA Medical Center), Nicole Kosik(VA Boston Healthcare System), Marijana Vujković(Philadelphia VA Medical Center), David Gagnon(Boston University), A. Patrícia Bento(European Bioinformatics Institute), Inigo Barrio‐Hernandez(European Bioinformatics Institute), Lars Rönnblom(Uppsala University), Niklas Hagberg(Uppsala University), Christian Lundtoft(Uppsala University), Claudia Langenberg(University of Cambridge), Maik Pietzner(University of Cambridge), Dennis Valentine(Health Data Research UK), Stefano Gustincich(Italian Institute of Technology), Gian Gaetano Tartaglia(Italian Institute of Technology), Elias Allara(University of Cambridge), Praveen Surendran(University of Cambridge), Stephen Burgess(University of Cambridge), Jing Hua Zhao(University of Cambridge), James E. Peters(University of Cambridge), Bram P. Prins(University of Cambridge), Emanuele Di Angelantonio(University of Cambridge), Poornima Devineni(VA Boston Healthcare System), Yunling Shi(VA Boston Healthcare System), Kristine E. Lynch(University of Utah), Scott L. DuVall(University of Utah), Helene Garcon(VA Boston Healthcare System), Lauren O. Thomann(VA Boston Healthcare System), Jin Zhou(University of Arizona), Bryan R. Gorman(VA Boston Healthcare System), Jennifer E. Huffman(VA Boston Healthcare System), Christopher J. O’Donnell(Brigham and Women's Hospital), Philip S. Tsao(VA Palo Alto Health Care System), Jean C. Beckham(Duke University), Saiju Pyarajan(VA Boston Healthcare System), Sumitra Muralidhar(VA Office of Research and Development), Grant D. Huang(VA Office of Research and Development), Rachel Ramoni(VA Office of Research and Development), Pedro Beltrão(European Bioinformatics Institute), John Danesh(University of Cambridge), Adriana M. Hung(Vanderbilt University), Kyong‐Mi Chang(Philadelphia VA Medical Center), Yan V. Sun(Emory University), Jacob Joseph(Brigham and Women's Hospital), Andrew R. Leach(European Bioinformatics Institute), Todd L. Edwards(Vanderbilt University), Kelly Cho(Brigham and Women's Hospital), J. Michael Gaziano(Brigham and Women's Hospital), Adam S. Butterworth(University of Cambridge), Juan P. Casas(Brigham and Women's Hospital), VA Million Veteran Program COVID-19 Science Initiative

Nature Medicine

April 1, 2021

10.1038/s41591-021-01310-z

Cited by 246Open Access

Full Text

Abstract

Related Papers

No related papers found

Powered by citation graph analysis