Anti-depression effect and mechanism of Suanzaoren Decoction on mice with depression

Huan Zhang(First Affiliated Hospital of Henan University), Yumei Ren(First Affiliated Hospital of Henan University), Meiqi Lv(First Affiliated Hospital of Henan University), Mengting Xie(First Affiliated Hospital of Henan University), Kai Wang(First Affiliated Hospital of Henan University), Mengjie Yang(First Affiliated Hospital of Henan University), Chengqi Lv(First Affiliated Hospital of Henan University), Xiaobing Li(First Affiliated Hospital of Henan University)
IOP Conference Series Earth and Environmental Science
March 1, 2021
10.1088/1755-1315/714/2/022065
Cited by 3Open Access
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Abstract

Abstract Objective: To study the therapeutic effect and mechanism of Suanzaoren Decoction on mice with depression. Methods: A model of depression was prepared by chronic unpredictable stimulation and reserpine induction. Behavioral tests, determination of norepinephrine and dopamine were performed. Results: The behavioral indicators of the model group were reduced, and the expression of norepinephrine and dopamine was decreased. Conclusion: Suanzaoren Decoction has an effect on the increase of serum norepinephrine and dopamine content, indicating that the jujube seed Soup has a certain effect on depression.

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