A highly multiplexed droplet digital PCR assay to measure the intact HIV-1 proviral reservoir

Claire Levy(University of Washington), Sean M. Hughes(University of Washington), Pavitra Roychoudhury(Fred Hutch Cancer Center), Daniel B. Reeves(Fred Hutch Cancer Center), Chelsea Amstuz(Fred Hutch Cancer Center), Haiying Zhu(University of Washington), Meei‐Li Huang(University of Washington), Yulun Wei(University of Washington), Marta E. Bull(University of Washington), Noah A.J. Cassidy(Fred Hutch Cancer Center), Jan McClure(University of Washington), Lisa M. Frenkel(University of Washington), Mars Stone(Pacific Research Institute), Sonia Bakkour(Pacific Research Institute), Elizabeth R. Wonderlich(Southern Research Institute), Michael P. Busch(Pacific Research Institute), Steven G. Deeks(San Francisco General Hospital), Joshua T. Schiffer(Fred Hutch Cancer Center), Robert W. Coombs(University of Washington), Dara A. Lehman(University of Washington), Keith R. Jerome(University of Washington), Florian Hladik(University of Washington)
Cell Reports Medicine
April 1, 2021
10.1016/j.xcrm.2021.100243
Cited by 106Open Access
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Abstract

T cells are faster for intact than for defective proviruses, and intact provirus frequencies are similar in mucosal and circulating T cells.

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