Generation of mature and functional hair cells by co-expression of Gfi1, Pou4f3, and Atoh1 in the postnatal mouse cochlea
Yan Chen(State Key Laboratory of Medical Neurobiology), Yuyan Gu(State Key Laboratory of Medical Neurobiology), Yige Li(Southeast University), Geng‐Lin Li(State Key Laboratory of Medical Neurobiology), Renjie Chai(Nantong University), Wenyan Li(Fudan University), Huawei Li(Fudan University)
Cited by 108Open Access
Abstract
current, fired spikes transiently, and exhibited signature refinement of ribbon synapse functions, in close resemblance to native wild-type inner HCs. We demonstrated that co-upregulating Gfi1, Pou4f3, and Atoh1 enhances the efficiency of HC generation and promotes the functional maturation of new HCs.
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