Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice

Lin Wang(SickKids Foundation), Spencer A. Freeman(University of Toronto), Meera Mehta(University of Toronto), Sarit Cohen‐Kedar(Tel Aviv University), Kaiyue Peng(Children's Hospital of Fudan University), Yuesheng Wang(Chinese Academy of Sciences), Liren Wang(SickKids Foundation), Neil Warner(SickKids Foundation), Melania Capitani(John Radcliffe Hospital), Conghui Guo(University of Toronto), Samuel J. Bullers(Nuffield Orthopaedic Centre), Daniel Mayr(Austrian Academy of Sciences), Ana‐Iris Schiefer(Medical University of Vienna), Iris Dotan(Tel Aviv University), Chien-Yi Lu(University of Toronto), Klaus Warnatz(University of Freiburg), Sophie Hambleton(Great North Children's Hospital), Gergely Kriván(National Center for Epidemiology), Michael G. Surette, Daniel Kotlarz(Medizinische Hochschule Hannover), Anís N. Gammage(Nuffield Orthopaedic Centre), Siew C. Ng(Chinese University of Hong Kong), Dilan Dissanayake(Hospital for Sick Children), Mathieu Lemaire(University of Toronto), Li Qi(University of Toronto), Helen Griffin(Centre for Life), Rico Chandra Ardy(Austrian Academy of Sciences), Iram Siddiqui(University of Toronto), Daniel J. Mulder(SickKids Foundation), Zhiyang Zeng(East China Normal University), Dominik Aschenbrenner(John Radcliffe Hospital), Jie Pan(University of Toronto), Karin R. Engelhardt(Newcastle University), Bodo Grimbacher(University of Freiburg), Vera Goda(National Center for Epidemiology), Suzanne Elcombe(Royal Victoria Infirmary), Tao Zuo(Sun Yat-sen University), Ronald M. Laxer(Hospital for Sick Children), Michele Proietti(University of Freiburg), Xiya Cao(East China Normal University), Robert Rottapel(St. Michael's Hospital), Xiaobing Wang(University of Science and Technology of China), Xiaoqin Li(Fujian Medical University), Zhiheng Huang(Third Affiliated Hospital of Zhengzhou University), Jiawei Lu(East China Normal University), Hélène Decaluwe(Centre Hospitalier Universitaire Sainte-Justine), Shuchao Li, Walter H.A. Kahr(University of Toronto)
Nature Genetics
March 29, 2021
Cited by 106


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