Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine <i>C</i>-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV

Richard L. Mackman(Gilead Sciences (United States)), Tomáš Cihlář(Gilead Sciences (United States)), Hon C. Hui(Gilead Sciences (United States)), Xianghan Lu(United States Military Academy), Raju Subramanian(Gilead Sciences (United States)), Diane S. Lye(Gilead Sciences (United States)), Kirsten M. Stray(Gilead Sciences (United States)), Darius Babusis(Gilead Sciences (United States)), Sarah Wortman(Gilead Sciences (United States)), Bin Ma(Tongji University), Venice Du Pont(Gilead Sciences (United States)), Cynthia Kim(Gilead Sciences (United States)), Daniel Byun(Gilead Sciences (United States)), Adelle A. Vandersteen(Gilead Sciences (United States)), Christopher A. Palmiotti(Gilead Sciences (United States)), Maria M. Toteva(Gilead Sciences (United States)), Kimberly T. Barrett(Gilead Sciences (United States)), Michel Perron(Gilead Sciences (United States)), Arya Vijjapurapu(Gilead Sciences (United States)), Scott P. Simonovich(Gilead Sciences (United States)), John P. Bilello(Global Vaccines (United States)), Gary Lee(Sir Charles Gairdner Hospital), Jared Pitts(Gilead Sciences (United States)), Eisuke Murakami(Gilead Sciences (United States)), Dustin S. Siegel(Gilead Sciences (United States)), Xiaofeng Zhao(Gilead Sciences (United States)), Robert Jordan(Gilead Sciences (United States)), Julie Chan(Gilead Sciences (United States)), Kwon Soo Chun(Gilead Sciences (United States)), Lijun Zhang(Dalian Medical University), Bindu Goyal(Gilead Sciences (United States))

Journal of Medicinal Chemistry

April 9, 2021

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