The Spectrum of Benefit from Checkpoint Blockade in Hypermutated Tumors

Benoı̂t Rousseau(Memorial Sloan Kettering Cancer Center), Michael B. Foote(Memorial Sloan Kettering Cancer Center), Steven B. Maron(Memorial Sloan Kettering Cancer Center), Bill H. Diplas(Memorial Sloan Kettering Cancer Center), Steve Lu(Johns Hopkins University), Guillem Argilés(Memorial Sloan Kettering Cancer Center), Andrea Cercek(Memorial Sloan Kettering Cancer Center), Luis A. Díaz(Memorial Sloan Kettering Cancer Center)
New England Journal of Medicine
March 24, 2021
Cited by 210Open Access
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Abstract

Immune Checkpoint Inhibitors and Tumor Mutational Burden The FDA has approved immune checkpoint inhibitors for solid tumors of any histologic origin with more than 10 mutations per megabase of DNA....


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