Deciphering epiblast lumenogenesis reveals proamniotic cavity control of embryo growth and patterning

Yung Su Kim(Max Planck Institute for Molecular Biomedicine), Rui Fan(Max Planck Institute for Molecular Biomedicine), Ludmila Kremer(Max Planck Institute for Molecular Biomedicine), Nannette Kuempel‐Rink(Max Planck Institute for Molecular Biomedicine), Karina Mildner(Max Planck Institute for Molecular Biomedicine), Dagmar Zeuschner(Max Planck Institute for Molecular Biomedicine), Liesbeth H.P. Hekking(Thermo Fisher Scientific (Netherlands)), Martin Stehling(Max Planck Institute for Molecular Biomedicine), Ivan Bedzhov(Max Planck Institute for Molecular Biomedicine)
Science Advances
March 10, 2021
10.1126/sciadv.abe1640
Cited by 50Open Access
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Abstract

Dissecting the mechanisms of lumen formation in the epiblast revealed that the proamniotic cavity acts as a central signaling hub.

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