Cytoplasmic DNA sensing by KU complex in aged CD4+ T cell potentiates T cell activation and aging-related autoimmune inflammation

Yan Wang; Zunyun Fu; Xutong Li; Yinming Liang; Siyu Pei; Shumeng Hao; Qingchen Zhu; Tao Yu; Yifei Pei; Jia Yuan; Jialin Ye; Jiemeng Fu; Jing Xu; Jin Hong; Ruirui Yang; Hui Hou; Xinfang Huang; Chao Peng; Mingyue Zheng; Yichuan Xiao

doi:10.1016/j.immuni.2021.02.003

Cytoplasmic DNA sensing by KU complex in aged CD4+ T cell potentiates T cell activation and aging-related autoimmune inflammation

Yan Wang(Shanghai Institute of Nutrition and Health), Zunyun Fu(Nanjing University of Chinese Medicine), Xutong Li(Shanghai Institute of Materia Medica), Yinming Liang(Henan Medical University), Siyu Pei(Shanghai Institute of Nutrition and Health), Shumeng Hao(Shanghai Institute of Nutrition and Health), Qingchen Zhu(Shanghai Institute of Nutrition and Health), Tao Yu(Shanghai Institute of Nutrition and Health), Yifei Pei(Shanghai Institute of Nutrition and Health), Jia Yuan(Shanghai Institute of Nutrition and Health), Jialin Ye(Shanghai Institute of Nutrition and Health), Jiemeng Fu(Shanghai Institute of Nutrition and Health), Jing Xu(Shanghai Institute of Nutrition and Health), Jin Hong(Ruijin Hospital), Ruirui Yang(ShanghaiTech University), Hui Hou(Shanghai Institute of Materia Medica), Xinfang Huang(Shanghai East Hospital), Chao Peng, Mingyue Zheng(Shanghai Institute of Materia Medica), Yichuan Xiao(Shanghai Institute of Nutrition and Health)

Immunity

March 5, 2021

10.1016/j.immuni.2021.02.003

Cited by 78Open Access

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