Prosaposin mediates inflammation in atherosclerosis
Mandy M. T. van Leent(Amsterdam University Medical Centers), Thijs J. Beldman(Radboud University Nijmegen), Yohana C. Toner(Icahn School of Medicine at Mount Sinai), Marnix Lameijer(Amsterdam University Medical Centers), Nils Rother(Radboud University Nijmegen), Siroon Bekkering(Radboud University Nijmegen), Abraham J. P. Teunissen(Icahn School of Medicine at Mount Sinai), Xianxiao Zhou(Icahn School of Medicine at Mount Sinai), Roy van der Meel(Eindhoven University of Technology), Joost Malkus(Icahn School of Medicine at Mount Sinai), Sheqouia A. Nauta(Icahn School of Medicine at Mount Sinai), Emma D. Klein(Icahn School of Medicine at Mount Sinai), François Fay(Centre National de la Recherche Scientifique), Brenda L. Sánchez-Gaytán(Benemérita Universidad Autónoma de Puebla), Carlos Pérez‐Medina(Spanish National Centre for Cardiovascular Research), Ewelina Kluza(Eindhoven University of Technology), Yuxiang Ye(STZ eyetrial), Gregory R. Wojtkiewicz(Center for Systems Biology), Edward A. Fisher(New York University), Filip K. Świrski(Center for Systems Biology), Matthias Nahrendorf(Center for Systems Biology), Bin Zhang(Centre for Individualised Infection Medicine), Yang Li(Radboud University Nijmegen), Bowen Zhang(Centre for Individualised Infection Medicine), Leo A. B. Joosten(Radboud University Nijmegen), Gerard Pasterkamp(Utrecht University), Arjan Boltjes(Utrecht University), Zahi A. Fayad(Icahn School of Medicine at Mount Sinai), Esther Lutgens(German Centre for Cardiovascular Research), Mihai G. Netea(University of Bonn), Niels P. Riksen(Radboud University Nijmegen), Willem J. M. Mulder(Radboud University Nijmegen), Raphaël Duivenvoorden(Radboud University Nijmegen)
Cited by 99Open Access
Abstract
expression and inflammation in human carotid atherosclerotic plaques. Our findings provide mechanistic insights into the development of atherosclerosis and identify prosaposin as a potential therapeutic target.
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