Pre-optimized phage therapy on secondary <i>Acinetobacter baumannii</i> infection in four critical COVID-19 patients
Nannan Wu(Shanghai Public Health Clinical Center), Jia Dai(Shanghai Public Health Clinical Center), Mingquan Guo(Shanghai Public Health Clinical Center), Jianhui Li(Shanghai Public Health Clinical Center), Xin Zhou(Shanghai Public Health Clinical Center), Feng Li(Shanghai Public Health Clinical Center), Yuan Gao(Shanghai Jiao Tong University), Hongping Qu(Shanghai Jiao Tong University), Hongzhou Lu(Shanghai Public Health Clinical Center), Jing Jin(Kai Biotech (South Korea)), Tao Li(Shanghai Public Health Clinical Center), Lei Shi(Shanghai Public Health Clinical Center), Qingguo Wu(Shanghai Public Health Clinical Center), Ruoming Tan(Shanghai Jiao Tong University), Mingli Zhu(Shanghai Jiao Tong University), Lan Yang(Shanghai Public Health Clinical Center), Yun Ling(Shanghai Public Health Clinical Center), Shunpeng Xing(Shanghai Jiao Tong University), Jianzhong Zhang(Sun Yat-sen University), Bangxin Yao(Sun Yat-sen University), Shuai Le(Army Medical University), Jingmin Gu(Jilin University), Jinhong Qin(Shanghai Jiao Tong University), Jie Li(Shanghai Public Health Clinical Center), Mengjun Cheng(Shanghai Public Health Clinical Center), Demeng Tan(Shanghai Public Health Clinical Center), Linlin Li(Shanghai Public Health Clinical Center), Yiyuan Zhang(Shanghai Public Health Clinical Center), Zhaoqin Zhu(Shanghai Public Health Clinical Center), Jinfeng Cai(Shanghai Public Health Clinical Center), Zhigang Song(Shanghai Public Health Clinical Center), Xiaokui Guo(Shanghai Jiao Tong University), Li‐Kuang Chen(Shanghai Public Health Clinical Center), Tongyu Zhu(Sun Yat-sen University)
Cited by 154Open Access
Abstract
plaque-forming unit phages). All patients in our COVID-19-specific intensive care unit (ICU) with CRAB positive in bronchoalveolar lavage fluid or sputum samples were eligible for study inclusion if antibiotic treatment failed to eradicate their CRAB infections. While phage susceptibility testing revealed an identical profile of CRAB strains from these patients, treatment with a pre-optimized 2-phage cocktail was associated with reduced CRAB burdens. Our results suggest the potential of phages on rapid responses to secondary CRAB outbreak in COVID-19 patients.
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