Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
Puya Gharahkhani(QIMR Berghofer Medical Research Institute), Eric Jorgenson(Kaiser Permanente), Pirro G. Hysi(King's College London), Anthony P. Khawaja(Moorfields Eye Hospital NHS Foundation Trust), Sarah A. Pendergrass(Geisinger Neuroscience Institute), Xikun Han(QIMR Berghofer Medical Research Institute), Jue‐Sheng Ong(QIMR Berghofer Medical Research Institute), Alex W. Hewitt(University of Tasmania), Ayellet V. Segrè(Harvard University), John M. Rouhana(Harvard University), Andrew R. Hamel(Harvard University), Robert P. Igo(Case Western Reserve University), Hélène Choquet(Kaiser Permanente), Ayub Qassim(Flinders University), Navya Shilpa Josyula, Jessica N. Cooke Bailey(University School), Pieter W. M. Bonnemaijer(Erasmus MC), Adriana I. Iglesias(Erasmus MC), Owen M. Siggs(Flinders University), Terri L. Young(University of Wisconsin–Madison), Véronique Vitart(Institute of Genetics and Cancer), Alberta A. H. J. Thiadens(Erasmus MC), Juha Karjalainen(Broad Institute), Steffen Uebe(Friedrich-Alexander-Universität Erlangen-Nürnberg), Ronald B. Melles, K. Saidas Nair(University of California, San Francisco), Robert Luben(University of Cambridge), Mark Simcoe(King's College London), Nishani Amersinghe(University Hospital Southampton NHS Foundation Trust), Angela J. Cree(University of Southampton), René Höhn(Johannes Gutenberg University Mainz), Alicia Poplawski(Johannes Gutenberg University Mainz), Li Jia Chen(Chinese University of Hong Kong), Shi Song Rong(Harvard University), Tin Aung(National University of Singapore), Eranga N. Vithana(National University of Singapore), R. Rand Allingham(Duke Medical Center), Murray H. Brilliant(Marshfield Clinic), Donald L. Budenz(University of North Carolina at Chapel Hill), Jessica N. Cooke Bailey(University School), John H. Fingert(University of Iowa), Douglas Gaasterland, Teresa Gaasterland(Scripps Institution of Oceanography), Jonathan L. Haines(University School), Michael A. Hauser(Duke University), Richard K. Lee(University of Miami), Paul R. Lichter(University of Michigan), Yutao Liu(Augusta University), Syoko Moroi(University of Michigan), Jonathan S. Myers(Wills Eye Hospital), Margaret A. Pericak‐Vance(University of Miami), Anthony Realini(West Virginia University), Doug Rhee(University School), Julia E. Richards(University of Michigan), Robert Ritch(New York Eye and Ear Infirmary), Joel S. Schuman(New York University), William K. Scott(University of Miami), Kuldev Singh(Stanford University), Arthur J. Sit(Mayo Clinic in Arizona), Douglas Vollrath(Stanford University), Robert N. Weinreb(University of California San Diego), Gadi Wollstein(New York University), Donald J. Zack(Johns Hopkins University), Shiwani Sharma(Flinders University), Sarah Martin(Flinders University), Tiger Zhou(Flinders University), Emmanuelle Souzeau(Flinders University), John E. Landers(Flinders University), Jude Fitzgerald(Flinders University), Richard Mills(Flinders University), Jamie E. Craig(Flinders University), Kathryn P. Burdon(University of Tasmania), Stuart L. Graham(Macquarie University), Robert J. Casson(The University of Adelaide), Ivan Goldberg(The University of Sydney), Andrew White(The University of Sydney), Paul R. Healey(The University of Sydney), David A. Mackey(Lions Eye Institute), Alex W. Hewitt(University of Tasmania), Biobank Japan project(Fukuoka Tokushukai Hospital), Masaki Shiono(Fukuoka Tokushukai Hospital), Kazuo Misumi(Fukuoka Tokushukai Hospital), Reiji Kaieda(Fukuoka Tokushukai Hospital), Hiromasa Harada(Fukuoka Tokushukai Hospital), Shiro Minami(Nippon Medical School), Mitsuru Emi(Nippon Medical School), Naoya Emoto(Juntendo University Hospital), Hiroyuki Daida(Juntendo University Hospital), Katsumi Miyauchi(Juntendo University Hospital), Akira Murakami(Nihon University), Satoshi Asai(Nihon University), Mitsuhiko Moriyama(Nihon University), Yasuo Takahashi(Nihon University), Tomoaki Fujioka(Iwate Medical University), Wataru Obara(Iwate Medical University), Seijiro Mori(Tokyo Metropolitan Institute of Gerontology), Hideki Ito(The Cancer Institute Hospital), Satoshi Nagayama(The Cancer Institute Hospital), Yoshio Miki(The Cancer Institute Hospital), Akihide Masumoto(Aso Iizuka Hospital), Akira Yamada(Aso Iizuka Hospital), Yasuko Nishizawa(Osaka International Cancer Institute), Ken Kodama(Shiga University of Medical Science), Hiromu Kutsumi(Shiga University of Medical Science), Yoshihisa Sugimoto(Shiga University of Medical Science), Yukihiro Koretsune(Osaka National Hospital), Hideo Kusuoka(Osaka National Hospital), Hideki Yanaiag(Fukujuji Hospital), Akiko Nagai(The University of Tokyo), Makoto Hirata(RIKEN Center for Integrative Medical Sciences), Yoichiro Kamatani(RIKEN Center for Integrative Medical Sciences), Kaori Muto(The University of Tokyo), Koichi Matsuda(Hisayama Research Institute For Lifestyle Diseases), Yutaka Kiyohara(Kyushu University), Toshiharu Ninomiya(Kyushu University), Akiko Tamakoshi(Hokkaido University), Zentaro Yamagata(RIKEN Center for Integrative Medical Sciences), Taisei Mushiroda(RIKEN Center for Integrative Medical Sciences), Yoshinori Murakami(Saitama International Medical Center), Koichiro Yuji(Saitama International Medical Center), Yoichi Furukawa(The University of Tokyo), Hitoshi Zembutsu(National Cancer Centre Japan), Toshihiro Tanaka(Tokyo Medical and Dental University), Yozo Ohnishi(Shinko Hospital), Yusuke Nakamura(University of Helsinki), FinnGen study(Pfizer (United States)), Anu Jalanko(University of Helsinki), Jaakko Kaprio(University of Helsinki), Kati Donner(University of Helsinki), Mari Kaunisto(University of Helsinki), Nina Mars(University of Helsinki), Alexander Dada(University of Helsinki), Anastasia Shcherban(University of Helsinki), Andrea Ganna(University of Helsinki), Arto Lehistö(University of Helsinki), Elina Kilpeläinen(University of Helsinki), Georg Brein(University of Helsinki), Awaisa Ghazal(University of Helsinki), Jarmo Harju(University of Helsinki), Kalle Pärn(University of Helsinki), Pietro Della Briotta Parolo(University of Helsinki), Risto Kajanne(University of Helsinki), Susanna Lemmelä(University of Helsinki), Timo P. Sipilä(University of Helsinki), Tuomas Sipilä(University of Helsinki), Ulrike Lyhs(University of Helsinki), Vincent Llorens(University of Helsinki), Teemu Niiranen(Finnish Institute for Health and Welfare), Kati Kristiansson(Finnish Institute for Health and Welfare), Lotta Männikkö(Finnish Institute for Health and Welfare), Manuel González Jiménez(Finnish Institute for Health and Welfare), Markus Perola(Finnish Institute for Health and Welfare), Regis Wong(Finnish Institute for Health and Welfare), Terhi Kilpi(Finnish Institute for Health and Welfare), Tero Hiekkalinna(Finnish Institute for Health and Welfare), Elina Järvensivu(Finnish Institute for Health and Welfare), Essi Kaiharju(Finnish Institute for Health and Welfare), Hannele Mattsson(Finnish Institute for Health and Welfare), Markku Laukkanen(Finnish Institute for Health and Welfare), Päivi Laiho(Finnish Institute for Health and Welfare), Sini Lähteenmäki(Finnish Institute for Health and Welfare), Tuuli Sistonen(AbbVie (United States)), Sirpa Soini(AbbVie (United States)), Adam Ziemann(AbbVie (United States)), Anne Lehtonen(AbbVie (United States)), Apinya Lertratanakul(AbbVie (United States)), Bob Georgantas(AbbVie (United States)), Bridget Riley‐Gillis(AbbVie (United States)), Danjuma Quarless(AbbVie (United States)), Fedik Rahimov(AbbVie (United States)), Graham Heap(AbbVie (United States)), Howard J. Jacob(AbbVie (United States)), Jeffrey F. Waring(AbbVie (United States)), J. Wade Davis(AbbVie (United States)), Nizar Smaoui(AbbVie (United States)), Relja Popovic(AbbVie (United States)), Sahar Esmaeeli(AstraZeneca (United Kingdom)), Jeff Waring(AstraZeneca (United Kingdom)), Athena Matakidou(AstraZeneca (United Kingdom)), Ben Challis(AstraZeneca (United Kingdom)), David A. Close(AstraZeneca (United Kingdom)), Slavé Petrovski(AstraZeneca (United Kingdom)), Antti Karlsson(University of Turku), Johanna Schleutker(University of Turku), Kari Pulkki(University of Turku), Petri Virolainen(University of Turku), Lila Kallio(University of Turku), Arto Mannermaa(University of Eastern Finland), Sami Heikkinen(Biogen (United States)), Veli‐Matti Kosma(Biogen (United States)), Chia‐Yen Chen(Biogen (United States)), Heiko Runz(Biogen (United States)), Jimmy Liu(Biogen (United States)), Paola G. Bronson(Biogen (United States)), Sally John(Biogen (United States)), Sanni Lahdenperä(Broad Institute), Susan Eaton(Biogen (United States)), Wei Zhou(Broad Institute), Minna Hendolin(Business Finland), Outi Tuovila(Business Finland), Raimo Pakkanen(Business Finland), Joseph Maranville, Keith Usiskin, Marla Hochfeld, Robert M. Plenge, Robert Yang, Shameek Biswas(Central Finland Health Care District), Steven M. Greenberg(Central Finland Health Care District), Eija K. Laakkonen(Central Finland Health Care District), Juha Kononen(Central Finland Health Care District), Juha Paloneva(Central Finland Health Care District), Urho M. Kujala(Central Finland Health Care District), Teijo Kuopio(Tampere University), Jari A. Laukkanen(Tampere University), Eeva Kangasniemi(Tampere University), Kimmo Savinainen(Tampere University), Reijo Laaksonen(Tampere University), Mikko Arvas(Tampere University), Jarmo Ritari(Tampere University), Jukka Partanen(Tampere University), Kati Hyvärinen(Tampere University), Tiina Wahlfors(Tampere University), Andrew S. Peterson, Danny Oh, Diana Chang, Edmond Teng, Erich C. Strauss, Geoff Kerchner, Hao Chen, Hubert Chen, Jennifer L. Schutzman, John A. Michon, Julie Hunkapiller, Mark I. McCarthy, Natalie Bowers, Tim Lu(GlaxoSmithKline (United Kingdom)), Tushar Bhangale(GlaxoSmithKline (United Kingdom)), David Pulford(GlaxoSmithKline (United Kingdom)), Dawn Waterworth(GlaxoSmithKline (United Kingdom)), Diptee Kulkarni(GlaxoSmithKline (United Kingdom)), Fanli Xu(GlaxoSmithKline (United Kingdom)), Jo Betts(GlaxoSmithKline (United Kingdom)), Jorge Esparza Gordillo(GlaxoSmithKline (United Kingdom)), Joshua Hoffman(GlaxoSmithKline (United Kingdom)), Kirsi Auro(GlaxoSmithKline (United Kingdom)), Linda McCarthy(GlaxoSmithKline (United Kingdom)), Soumitra Ghosh(GlaxoSmithKline (United Kingdom)), Meg Ehm(University of Helsinki), Kimmo Pitkänen(Hospital District of Helsinki and Uusimaa), Tomi P. Mäkelä(University of Helsinki), Anu Loukola(Hospital District of Helsinki and Uusimaa), Heikki Joensuu(Hospital District of Helsinki and Uusimaa), Juha Sinisalo(Hospital District of Helsinki and Uusimaa), Kari K. Eklund(Hospital District of Helsinki and Uusimaa), Lauri A. Aaltonen(Hospital District of Helsinki and Uusimaa), Martti Färkkilâ(Hospital District of Helsinki and Uusimaa), Olli Carpén(Hospital District of Helsinki and Uusimaa), Paula Kauppi(Hospital District of Helsinki and Uusimaa), Pentti Tienari(Hospital District of Helsinki and Uusimaa), Terhi Ollila(Hospital District of Helsinki and Uusimaa), Tiinamaija Tuomi(Hospital District of Helsinki and Uusimaa), Tuomo J Meretoja(Hospital District of Helsinki and Uusimaa), Anne Pitkäranta(Hospital District of Helsinki and Uusimaa), Joni A. Turunen(Hospital District of Helsinki and Uusimaa), Katariina Hannula‐Jouppi(Hospital District of Helsinki and Uusimaa), Sampsa Pikkarainen(Hospital District of Helsinki and Uusimaa), Sanna Seitsonen(Varsinais-Suomen Sairaanhoitopiiri), Miika Koskinen(Varsinais-Suomen Sairaanhoitopiiri), Antti Palomäki(Varsinais-Suomen Sairaanhoitopiiri), Juha O. Rinne(Varsinais-Suomen Sairaanhoitopiiri), Kaj Metsärinne(Varsinais-Suomen Sairaanhoitopiiri), Klaus Elenius(Varsinais-Suomen Sairaanhoitopiiri), Laura Pirilä(Varsinais-Suomen Sairaanhoitopiiri), Leena Koulu(Varsinais-Suomen Sairaanhoitopiiri), Markku Voutilainen(Varsinais-Suomen Sairaanhoitopiiri), Markus Juonala(Varsinais-Suomen Sairaanhoitopiiri), Sirkku Peltonen(Merck & Co., Inc., Rahway, NJ, USA (United States)), Vesa Aaltonen(Merck & Co., Inc., Rahway, NJ, USA (United States)), Andrey Loboda(Merck & Co., Inc., Rahway, NJ, USA (United States)), Anna Podgornaia(Merck & Co., Inc., Rahway, NJ, USA (United States)), Aparna Chhibber(Merck & Co., Inc., Rahway, NJ, USA (United States)), Audrey Y. Chu(Merck & Co., Inc., Rahway, NJ, USA (United States)), Caroline S. Fox(Merck & Co., Inc., Rahway, NJ, USA (United States)), Dorothée Diogo(Merck & Co., Inc., Rahway, NJ, USA (United States)), Emily Holzinger(Merck & Co., Inc., Rahway, NJ, USA (United States)), John D. Eicher(Merck & Co., Inc., Rahway, NJ, USA (United States)), Padhraig Gormley(Merck & Co., Inc., Rahway, NJ, USA (United States)), Vinay Mehta(Merck & Co., Inc., Rahway, NJ, USA (United States)), Xulong Wang(23andMe (United States)), Johannes Kettunen(Borealis (Finland)), Katri Pylkäs(Borealis (Finland)), Marita Kalaoja(Borealis (Finland)), Minna K. Karjalainen(Borealis (Finland)), Reetta Hinttala(Borealis (Finland)), Riitta Kaarteenaho(Borealis (Finland)), Seppo Vainio(Borealis (Finland)), Tuomo Mantere(Borealis (Finland)), Anne M. Remes(Northern Ostrobothnia Hospital District), Johanna Huhtakangas(Northern Ostrobothnia Hospital District), Juhani Junttila(Northern Ostrobothnia Hospital District), Kaisa Tasanen(Northern Ostrobothnia Hospital District), Laura Huilaja(Northern Ostrobothnia Hospital District), Marja Luodonpää(Northern Ostrobothnia Hospital District), Nina Hautala(Northern Ostrobothnia Hospital District), Peeter Karihtala(Northern Ostrobothnia Hospital District), Saila Kauppila(Northern Ostrobothnia Hospital District), Terttu Harju(Northern Ostrobothnia Hospital District), Timo Blomster(Northern Ostrobothnia Hospital District), Hilkka Soininen, Ilkka T. Harvima, Jussi Pihlajamäki, Kai Kaarniranta, Margit Pelkonen, Markku Laakso, Mikko Hiltunen, Mikko Kiviniemi, Oili Kaipiainen‐Seppänen, Päivi Auvinen, Reetta Kälviäinen(Pfizer (United States)), Valtteri Julkunen(Pfizer (United States)), Anders Mälarstig(Pfizer (United States)), Åsa K. Hedman(Pfizer (United States)), Catherine Marshall(Pfizer (United States)), Christopher D. Whelan(Pfizer (United States)), Heli Lehtonen(Pfizer (United States)), Jaakko Parkkinen(Pfizer (United States)), Kari Linden(Pfizer (United States)), Kirsi Kalpala(Pfizer (United States)), Melissa Miller(Pfizer (United States)), Nan Bing(Pfizer (United States)), Stefan McDonough(Pfizer (United States)), Xing Chen(Pfizer (United States)), Xinli Hu(Pfizer (United States)), Ying Wu(Pfizer (United States)), Annika Auranen(Pirkanmaa Hospital District), Airi Jussila(Pfizer (United States)), Hannele Uusitalo‐Järvinen(Pirkanmaa Hospital District), Hannu Kankaanranta(Pirkanmaa Hospital District), Hannu Uusitalo(Pirkanmaa Hospital District), Jukka Peltola(Pirkanmaa Hospital District), Mika Kähönen(Pirkanmaa Hospital District), Pia Isomäki(Pirkanmaa Hospital District), Tarja Laitinen(Sanofi (France)), Teea Salmi(Sanofi (France)), Anthony J. Muslin(Sanofi (France)), Clarence Wang(Sanofi (France)), Clément Chatelain(Sanofi (France)), Ethan Xu(Sanofi (France)), Franck Augé(Sanofi (France)), Kathy Call(Sanofi (France)), Kathy Klinger(Sanofi (France)), Marika Crohns(University of Helsinki), Matthias Gossel(Sanofi (France)), Kimmo Palin(University of Helsinki), Manuel A. Rivas(Tampere University), Harri Siirtola(Tampere University), Javier Gracia‐Tabuenca(Tampere University), Tariq Aslam(University of Leeds), Sarah Barman(Kingston University), Jenny Barrett(University of Leeds), Paul Bishop(University of Manchester), Catey Bunce(Queen's University Belfast), Roxana O. Carare(Moorfields Eye Hospital), Usha Chakravarthy(Queen's University Belfast), Michelle Chan(Moorfields Eye Hospital), Valentina Cipriani(Moorfields Eye Hospital), Alexander Day(Moorfields Eye Hospital), Parul Desai(University of Bristol), Bal Dhillon(Moorfields Eye Hospital), Andrew D. Dick(University of Bristol), Cathy Egan(Moorfields Eye Hospital), Sarah Ennis(University of Southampton), Paul J. Foster(Moorfields Eye Hospital NHS Foundation Trust), Marcus Fruttiger(University College London), John Gallacher(University of Oxford), David F. Garway‐Heath(Moorfields Eye Hospital), Jane Whitney Gibson(University of Southampton), Dan Gore(Moorfields Eye Hospital), Jeremy A. Guggenheim(University of Liverpool), Alison J. Hardcastle(Queen's University Belfast), Simon Harding(University of Liverpool), Ruth Hogg(Queen's University Belfast), Pearse A. Keane(University of Cambridge), Peng T. Khaw(Moorfields Eye Hospital NHS Foundation Trust), Anthony P. Khawaja(Moorfields Eye Hospital NHS Foundation Trust), Gerassimos Lascaratos(Moorfields Eye Hospital), Andrew Lotery(University Hospital Southampton NHS Foundation Trust), Philip J. Luthert(University of Leeds), Tom MacGillivray(Queen's University Belfast), Sarah Mackie(Queen's University Belfast), Bernadette McGuinness(Queen's University Belfast), Gareth J. McKay(Queen's University Belfast), Martin McKibbin(Leeds Teaching Hospitals NHS Trust), Danny Mitry(Cardiff University), Tony Moore(University College London), James P. Morgan(King's College Hospital), Zaynah Muthy(St George's, University of London), Eoin O’Sullivan(Moorfields Eye Hospital), Christopher G. Owen(Queen's University Belfast), Praveen J. Patel(Queen's University Belfast), Euan Paterson(Queen's University Belfast), Tünde Pető(Queen's University Belfast), Axel Petzold(St George's, University of London), Jugnoo S. Rahi(University of Southampton), Alicja R. Rudnicka(St George's, University of London), Jay Self(Moorfields Eye Hospital), Sobha Sivaprasad(Gloucestershire Hospitals NHS Foundation Trust), David Steel(Moorfields Eye Hospital), Irene Stratton(Gloucestershire Hospitals NHS Foundation Trust), Nicholas G. Strouthidis(Moorfields Eye Hospital NHS Foundation Trust), Cathie Sudlow(Moorfields Eye Hospital), Caroline Thaung(University of Dundee), Dhanes Thomas(Moorfields Eye Hospital), Emanuele Trucco(University of Nottingham), Adnan Tufail(Moorfields Eye Hospital), S A Vernon(University of Nottingham), Ananth C. Viswanathan(King's College London), Cathy Williams(Queen's University Belfast), Katie Williams(University of East Anglia), Jayne V. Woodside(Queen's University Belfast), Max Yates(University of East Anglia), Jennifer Yip(St George's, University of London), Yalin Zheng(University of Liverpool), Robyn J. Tapp(St George's, University of London), Denize Atan(University of Bristol), Alex S. F. Doney(University of Dundee), Naomi E. Allen(University of Manchester), Thomas J. Littlejohns(University of Manchester), Panagiotis I. Sergouniotis(Muhimbili University of Health and Allied Sciences), Graeme C. Black(University of Manchester), GIGA study group(National Institute for Medical Research), Neema Kanyaro(Muhimbili University of Health and Allied Sciences), Cyprian Ntomoka(23andMe (United States)), Julius J. Massaga(23andMe (United States)), Joyce K. Ikungura(23andMe (United States)), Michelle Agee(23andMe (United States)), Stella Aslibekyan(23andMe (United States)), Robert K. Bell(23andMe (United States)), Katarzyna Bryc(23andMe (United States)), Sarah Clark(23andMe (United States)), Sarah L. Elson(23andMe (United States)), Kipper Fletez‐Brant(23andMe (United States)), Pierre Fontanillas(23andMe (United States)), Nicholas A. Furlotte(23andMe (United States)), Pooja Gandhi(23andMe (United States)), Karl Heilbron(23andMe (United States)), Barry Hicks(23andMe (United States)), David A. Hinds(23andMe (United States)), Karen E. Huber(23andMe (United States)), Ethan M. Jewett(23andMe (United States)), Yunxuan Jiang(23andMe (United States)), Aaron Kleinman(23andMe (United States)), Keng‐Han Lin(23andMe (United States)), Nadia K. Litterman(23andMe (United States)), Jennifer C. McCreight(23andMe (United States)), Matthew H. McIntyre(23andMe (United States)), Kimberly F. McManus(23andMe (United States)), Joanna L. Mountain(23andMe (United States)), Sahar V. Mozaffari(23andMe (United States)), Priyanka Nandakumar(23andMe (United States)), Elizabeth S. Noblin(23andMe (United States)), Carrie A. M. Northover(23andMe (United States)), Jared O’Connell(23andMe (United States)), Steven J. Pitts(23andMe (United States)), G. David Poznik(23andMe (United States)), J. Fah Sathirapongsasuti(23andMe (United States)), Anjali J. Shastri(23andMe (United States)), Janie F. Shelton(23andMe (United States)), Suyash Shringarpure(23andMe (United States)), Chao Tian(23andMe (United States)), Joyce Y. Tung(23andMe (United States)), Robert J. Tunney(23andMe (United States)), Vladimir Vacic(Tohoku University), Amir S. Zare(Tohoku University), Gen Tamiya(Tohoku University), Yukihiro Shiga(European Bioinformatics Institute), Masayuki Yamamoto(European Bioinformatics Institute), Toru Nakazawa(Tohoku University), Hannah Currant(European Bioinformatics Institute), Ewan Birney(European Bioinformatics Institute), Xin Wang(QIMR Berghofer Medical Research Institute), Adam Auton(University of Ibadan), Michelle K. Lupton(University of Ibadan), Nicholas G. Martin(University of the Witwatersrand), Adeyinka Ashaye(University of Ghana), Olusola Olawoye(University of Ibadan), Susan Williams(University of the Witwatersrand), Stephen Akafo(University of Ghana), Michèle Ramsay(Kyushu University), Kazuki Hashimoto(Tohoku University), Yoichiro Kamatani(RIKEN Center for Integrative Medical Sciences), Masato Akiyama(Kyushu University), Yukihide Momozawa(RIKEN Center for Integrative Medical Sciences), Paul J. Foster(Moorfields Eye Hospital NHS Foundation Trust), Peng T. Khaw(Moorfields Eye Hospital NHS Foundation Trust), James E. Morgan(Brigham and Women's Hospital), Nicholas G. Strouthidis(Moorfields Eye Hospital NHS Foundation Trust), Peter Kraft(Harvard University), Jae H. Kang(Brigham and Women's Hospital), Chi Pui Pang(Chinese University of Hong Kong), Francesca Pasutto(Broad Institute), Paul Mitchell(The University of Sydney), Andrew Lotery(University Hospital Southampton NHS Foundation Trust), Aarno Palotie(Broad Institute), Cornelia M. van Duijn(Erasmus MC), Jonathan L. Haines(University School), Christopher J. Hammond(King's College London), Louis R. Pasquale(Genome Institute of Singapore), Caroline C. W. Klaver(Lions Eye Institute), Michael Hauser(Duke University), Chiea Chuen Khor(National University of Singapore), David A. Mackey(Lions Eye Institute), Michiaki Kubo(QIMR Berghofer Medical Research Institute), Ching‐Yu Cheng(Harvard University), Jamie E. Craig(Flinders University), Stuart MacGregor(QIMR Berghofer Medical Research Institute), Janey L. Wiggs(Harvard University)
Cited by 486Open Access
Abstract
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 controls, identifying 44 previously unreported risk loci and confirming 83 loci that were previously known. The majority of loci have broadly consistent effects across European, Asian and African ancestries. Cross-ancestry data improve fine-mapping of causal variants for several loci. Integration of multiple lines of genetic evidence support the functional relevance of the identified POAG risk loci and highlight potential contributions of several genes to POAG pathogenesis, including SVEP1, RERE, VCAM1, ZNF638, CLIC5, SLC2A12, YAP1, MXRA5, and SMAD6. Several drug compounds targeting POAG risk genes may be potential glaucoma therapeutic candidates.
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