A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage

Xueqing Zou; Gene Ching Chiek Koh; Arjun S. Nanda; Andrea Degasperi; Katie Urgo; Theodoros I. Roumeliotis; Chukwuma A. Agu; Cherif Badja; Sophie Momen; Jamie Young; Tauanne Dias Amarante; Lucy Side; Glen Brice; Vanesa Pérez‐Alonso; Daniel Rueda; Céline Gomez; Wendy Bushell; Rebecca Harris; Jyoti S. Choudhary; John C. Ambrose; Prabhu Arumugam; Emma L. Baple; Marta Bleda; Freya Boardman-Pretty; Jeanne M. Boissiere; C. R. Boustred; Helen Brittain; Mark J. Caulfield; G. C. Chan; Clare Craig; Louise C. Daugherty; Anna de Burca; A. Devereau; Greg Elgar; Rebecca E. Foulger; Tom Fowler; Pedro Furió‐Tarí; Adam Giess; Joanne M. Hackett; Dina Halai; Angela Hamblin; Shirley Henderson; J. Holman; Tim Hubbard; Kristina Ibáñez; Robert W. Jackson; J. Louise Jones; Dalia Kasperavičiūtė; Melis Kayikci; Athanasios Kousathanas; L. Lahnstein; Kay Lawson; S. E. A. Leigh; I. U. S. Leong; Javier Ferreiros; F. Maleady-Crowe; Joanne Mason; Ellen M. McDonagh; Loukas Moutsianas; Michael Mueller; Nirupa Murugaesu; Anna C. Need; Pter O’Donovan; Chris A. Odhams; Andrea Orioli; Christine Patch; Mariana Buongermino Pereira; D. Perez-Gil; Dimitris Polychronopoulos; J. Pullinger; T. Rahim; Augusto Rendon; Pablo Riesgo-Ferreiro; Tim Rogers; Mina Ryten; K. Savage; Kushmita Sawant; Richard H. Scott; Afshan Siddiq; A. Sieghart; Damian Smedley; Katherine R. Smith; Samuel C. Smith; Alona Sosinsky; William Spooner; Helen E. Stevens; Alexander Stuckey; Răzvan Sultana; M. Tanguy; Ellen Thomas; Simon R. Thompson; Carolyn Tregidgo; Arianna Tucci; Emma Walsh; Sarah A. Watters; M. J. Welland; Eleanor Williams; Katarzyna Witkowska; S. M. Wood; Magdalena Zarowiecki; Josef Jiricny; William C. Skarnes; Serena Nik‐Zainal

doi:10.1038/s43018-021-00200-0

A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage

Xueqing Zou(University of Cambridge), Gene Ching Chiek Koh(University of Cambridge), Arjun S. Nanda(University of Cambridge), Andrea Degasperi(University of Cambridge), Katie Urgo(Wellcome Sanger Institute), Theodoros I. Roumeliotis(Institute of Cancer Research), Chukwuma A. Agu(Wellcome Sanger Institute), Cherif Badja(University of Cambridge), Sophie Momen(University of Cambridge), Jamie Young(University of Cambridge), Tauanne Dias Amarante(University of Cambridge), Lucy Side(Great Ormond Street Hospital), Glen Brice(St George's, University of London), Vanesa Pérez‐Alonso(Research Institute Hospital 12 de Octubre), Daniel Rueda(Research Institute Hospital 12 de Octubre), Céline Gomez(Wellcome Sanger Institute), Wendy Bushell(Wellcome Sanger Institute), Rebecca Harris(University of Cambridge), Jyoti S. Choudhary(Institute of Cancer Research), John C. Ambrose(Jackson Laboratory), Prabhu Arumugam(Jackson Laboratory), Emma L. Baple(Jackson Laboratory), Marta Bleda(Jackson Laboratory), Freya Boardman-Pretty(Jackson Laboratory), Jeanne M. Boissiere(Jackson Laboratory), C. R. Boustred(Jackson Laboratory), Helen Brittain(Jackson Laboratory), Mark J. Caulfield(Jackson Laboratory), G. C. Chan(Jackson Laboratory), Clare Craig(Jackson Laboratory), Louise C. Daugherty(Jackson Laboratory), Anna de Burca(Jackson Laboratory), A. Devereau(Jackson Laboratory), Greg Elgar(Jackson Laboratory), Rebecca E. Foulger(Jackson Laboratory), Tom Fowler(Jackson Laboratory), Pedro Furió‐Tarí(Jackson Laboratory), Adam Giess(Jackson Laboratory), Joanne M. Hackett(Jackson Laboratory), Dina Halai(Jackson Laboratory), Angela Hamblin(Jackson Laboratory), Shirley Henderson(Jackson Laboratory), J. Holman(Jackson Laboratory), Tim Hubbard(Jackson Laboratory), Kristina Ibáñez(Jackson Laboratory), Robert W. Jackson(Jackson Laboratory), J. Louise Jones(Jackson Laboratory), Dalia Kasperavičiūtė(Jackson Laboratory), Melis Kayikci(Jackson Laboratory), Athanasios Kousathanas(Jackson Laboratory), L. Lahnstein(Jackson Laboratory), Kay Lawson(Jackson Laboratory), S. E. A. Leigh(Jackson Laboratory), I. U. S. Leong(Jackson Laboratory), Javier Ferreiros(Jackson Laboratory), F. Maleady-Crowe(Jackson Laboratory), Joanne Mason(Jackson Laboratory), Ellen M. McDonagh(Jackson Laboratory), Loukas Moutsianas(Jackson Laboratory), Michael Mueller(Jackson Laboratory), Nirupa Murugaesu(Jackson Laboratory), Anna C. Need(Jackson Laboratory), Pter O’Donovan(Jackson Laboratory), Chris A. Odhams(Jackson Laboratory), Andrea Orioli(Jackson Laboratory), Christine Patch(Jackson Laboratory), Mariana Buongermino Pereira(Jackson Laboratory), D. Perez-Gil(Jackson Laboratory), Dimitris Polychronopoulos(Jackson Laboratory), J. Pullinger(Jackson Laboratory), T. Rahim(Jackson Laboratory), Augusto Rendon(Jackson Laboratory), Pablo Riesgo-Ferreiro(Jackson Laboratory), Tim Rogers(Jackson Laboratory), Mina Ryten(Jackson Laboratory), K. Savage(Jackson Laboratory), Kushmita Sawant(Jackson Laboratory), Richard H. Scott(Jackson Laboratory), Afshan Siddiq(Jackson Laboratory), A. Sieghart(Jackson Laboratory), Damian Smedley(Jackson Laboratory), Katherine R. Smith(Jackson Laboratory), Samuel C. Smith(Jackson Laboratory), Alona Sosinsky(Jackson Laboratory), William Spooner(Jackson Laboratory), Helen E. Stevens(Jackson Laboratory), Alexander Stuckey(Jackson Laboratory), Răzvan Sultana(Jackson Laboratory), M. Tanguy(Jackson Laboratory), Ellen Thomas(Jackson Laboratory), Simon R. Thompson(Jackson Laboratory), Carolyn Tregidgo(Jackson Laboratory), Arianna Tucci(Jackson Laboratory), Emma Walsh(Jackson Laboratory), Sarah A. Watters(Jackson Laboratory), M. J. Welland(Jackson Laboratory), Eleanor Williams(Jackson Laboratory), Katarzyna Witkowska(Jackson Laboratory), S. M. Wood(Jackson Laboratory), Magdalena Zarowiecki(Jackson Laboratory), Josef Jiricny(University of Zurich), William C. Skarnes(Queen Mary University of London), Serena Nik‐Zainal(Wellcome Sanger Institute)

Nature Cancer

April 26, 2021

10.1038/s43018-021-00200-0

Cited by 165Open Access

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