Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

Daniel E. Murphy(University Medical Center Utrecht), Olivier G. de Jong(University Medical Center Utrecht), Martijn J.W. Evers(University Medical Center Utrecht), Maratussholikhah Nurazizah(University Medical Center Utrecht), Raymond M. Schiffelers(University Medical Center Utrecht), Pieter Vader(University Medical Center Utrecht)
Nano Letters
February 11, 2021
10.1021/acs.nanolett.1c00094
Cited by 164Open Access
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Abstract

transfection reagents. We found that EVs delivered RNA several orders of magnitude more efficiently than these synthetic systems. This finding supports the continued research into EVs as potential RNA delivery vehicles.

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