Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

Bryan A. Johnson; Xuping Xie; Adam L. Bailey; Birte Kalveram; Kumari G. Lokugamage; Antonio E. Muruato; Jing Zou; Xianwen Zhang; Terry L. Juelich; Jennifer K. Smith; Lihong Zhang; Nathen E. Bopp; Craig Schindewolf; Michelle N. Vu; Abigail Vanderheiden; Emma S. Winkler; Daniele M. Swetnam; Jessica A. Plante; Patricia Aguilar; Kenneth S. Plante; Vsevolod L. Popov; Benhur Lee; Scott C. Weaver; Mehul S. Suthar; Andrew Routh; Ping Ren; Zhiqiang Ku; Zhiqiang An; Kari Debbink; Michael Diamond; Pei‐Yong Shi; Alexander N. Freiberg; Vineet D. Menachery

doi:10.1038/s41586-021-03237-4

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

Bryan A. Johnson(The University of Texas Medical Branch at Galveston), Xuping Xie(The University of Texas Medical Branch at Galveston), Adam L. Bailey(Washington University in St. Louis), Birte Kalveram(The University of Texas Medical Branch at Galveston), Kumari G. Lokugamage(The University of Texas Medical Branch at Galveston), Antonio E. Muruato(The University of Texas Medical Branch at Galveston), Jing Zou(The University of Texas Medical Branch at Galveston), Xianwen Zhang(The University of Texas Medical Branch at Galveston), Terry L. Juelich(The University of Texas Medical Branch at Galveston), Jennifer K. Smith(The University of Texas Medical Branch at Galveston), Lihong Zhang(The University of Texas Medical Branch at Galveston), Nathen E. Bopp(The University of Texas Medical Branch at Galveston), Craig Schindewolf(The University of Texas Medical Branch at Galveston), Michelle N. Vu(The University of Texas Medical Branch at Galveston), Abigail Vanderheiden(Emory University), Emma S. Winkler(Washington University in St. Louis), Daniele M. Swetnam(The University of Texas Medical Branch at Galveston), Jessica A. Plante(The University of Texas Medical Branch at Galveston), Patricia Aguilar(The University of Texas Medical Branch at Galveston), Kenneth S. Plante(The University of Texas Medical Branch at Galveston), Vsevolod L. Popov(The University of Texas Medical Branch at Galveston), Benhur Lee(Icahn School of Medicine at Mount Sinai), Scott C. Weaver(The University of Texas Medical Branch at Galveston), Mehul S. Suthar(Emory University), Andrew Routh(The University of Texas Medical Branch at Galveston), Ping Ren(The University of Texas Medical Branch at Galveston), Zhiqiang Ku(Brown Foundation), Zhiqiang An(Brown Foundation), Kari Debbink(Bowie State University), Michael Diamond(Washington University in St. Louis), Pei‐Yong Shi(The University of Texas Medical Branch at Galveston), Alexander N. Freiberg(The University of Texas Medical Branch at Galveston), Vineet D. Menachery(The University of Texas Medical Branch at Galveston)

Nature

January 25, 2021

10.1038/s41586-021-03237-4

Cited by 781Open Access

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