Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

Nicole E. Scharping(UPMC Hillman Cancer Center), Dayana B. Rivadeneira(UPMC Hillman Cancer Center), Ashley V. Menk(UPMC Hillman Cancer Center), Paolo Vignali(UPMC Hillman Cancer Center), B. Rhodes Ford(University of Pittsburgh), Natalie Rittenhouse(University of Pittsburgh), Ronal M. Peralta(UPMC Hillman Cancer Center), Yiyang Wang(Tsinghua University), Yupeng Wang(Tsinghua University), Kristin DePeaux(UPMC Hillman Cancer Center), Amanda C. Poholek(University of Pittsburgh), Greg M. Delgoffe(UPMC Hillman Cancer Center)
Nature Immunology
January 4, 2021
10.1038/s41590-020-00834-9
Cited by 835Open Access
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