<i>O</i> -GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis

Jinsu Park(Sungkyunkwan University), Hee-Jin Ha(Sungkyunkwan University), Eun Seon Chung(Tufts University), Seung Hyun Baek(Sungkyunkwan University), Yoonsuk Cho(Sungkyunkwan University), Hark Kyun Kim(Sungkyunkwan University), Jihoon Han(Sungkyunkwan University), Jae Hoon Sul(Sungkyunkwan University), Jeongmi Lee(Sungkyunkwan University), Eunae Kim(Sungkyunkwan University), Junsik Kim(Sungkyunkwan University), Yong Ryoul Yang(Korea Research Institute of Bioscience and Biotechnology), Mikyoung Park(Korea Institute of Brain Science), Sung Hyun Kim(Kyung Hee University), Thiruma V. Arumugam(La Trobe University), Hyemin Jang(Samsung Medical Center), Sang Won Seo(Samsung Medical Center), Pann‐Ghill Suh(Korea Brain Research Institute), Dong‐Gyu Jo(Sungkyunkwan University)
Science Advances
January 13, 2021
Cited by 143Open Access
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Abstract

Increased O -GlcNAcylation can confer neuroprotective effects against necroptosis in the context of Alzheimer’s disease.


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