Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19

Michael J. Joyner(Johns Hopkins University), Rickey E. Carter(Johns Hopkins University), Jonathon W. Senefeld(Johns Hopkins University), Stephen A. Klassen(Johns Hopkins University), John R. Mills(Johns Hopkins University), Patrick W. Johnson(Johns Hopkins University), Elitza S. Theel(Johns Hopkins University), Chad C. Wiggins(Johns Hopkins University), Katelyn A. Bruno(Johns Hopkins University), Allan M. Klompas(Johns Hopkins University), Elizabeth R. Lesser(Johns Hopkins University), Katie L. Kunze(Johns Hopkins University), Matthew A. Sexton(Johns Hopkins University), Juan C. Diaz Soto(Johns Hopkins University), Sarah E. Baker(Johns Hopkins University), John R.A. Shepherd(Johns Hopkins University), Noud van Helmond(Johns Hopkins University), Nicole Verdun(Johns Hopkins University), Peter Marks(Johns Hopkins University), Camille M. van Buskirk(Johns Hopkins University), Jeffrey L. Winters(Johns Hopkins University), James R. Stubbs(Johns Hopkins University), Robert F. Rea(Johns Hopkins University), David O. Hodge(Johns Hopkins University), Vitaly Herasevich(Johns Hopkins University), Emily R. Whelan(Johns Hopkins University), Andrew J. Clayburn(Johns Hopkins University), Kathryn F. Larson(Johns Hopkins University), Juan G. Ripoll(Johns Hopkins University), Kylie J. Andersen(Johns Hopkins University), Matthew Buras(Johns Hopkins University), Matthew N.P. Vogt(Johns Hopkins University), Joshua J. Dennis(Johns Hopkins University), Riley J. Regimbal(Johns Hopkins University), Philippe R. Bauer(Johns Hopkins University), Janis E. Blair(Johns Hopkins University), Nigel Paneth(Johns Hopkins University), DeLisa Fairweather(Johns Hopkins University), R. Scott Wright(Johns Hopkins University), Arturo Casadevall(Johns Hopkins University)
New England Journal of Medicine
January 13, 2021
10.1056/nejmoa2031893
Cited by 553Open Access
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Abstract

BACKGROUND: Convalescent plasma has been widely used to treat coronavirus disease 2019 (Covid-19) under the presumption that such plasma contains potentially therapeutic antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can be passively transferred to the plasma recipient. Whether convalescent plasma with high antibody levels rather than low antibody levels is associated with a lower risk of death is unknown. METHODS: In a retrospective study based on a U.S. national registry, we determined the anti-SARS-CoV-2 IgG antibody levels in convalescent plasma used to treat hospitalized adults with Covid-19. The primary outcome was death within 30 days after plasma transfusion. Patients who were enrolled through July 4, 2020, and for whom data on anti-SARS-CoV-2 antibody levels in plasma transfusions and on 30-day mortality were available were included in the analysis. RESULTS: Of the 3082 patients included in this analysis, death within 30 days after plasma transfusion occurred in 115 of 515 patients (22.3%) in the high-titer group, 549 of 2006 patients (27.4%) in the medium-titer group, and 166 of 561 patients (29.6%) in the low-titer group. The association of anti-SARS-CoV-2 antibody levels with the risk of death from Covid-19 was moderated by mechanical ventilation status. A lower risk of death within 30 days in the high-titer group than in the low-titer group was observed among patients who had not received mechanical ventilation before transfusion (relative risk, 0.66; 95% confidence interval [CI], 0.48 to 0.91), and no effect on the risk of death was observed among patients who had received mechanical ventilation (relative risk, 1.02; 95% CI, 0.78 to 1.32). CONCLUSIONS: Among patients hospitalized with Covid-19 who were not receiving mechanical ventilation, transfusion of plasma with higher anti-SARS-CoV-2 IgG antibody levels was associated with a lower risk of death than transfusion of plasma with lower antibody levels. (Funded by the Department of Health and Human Services and others; ClinicalTrials.gov number, NCT04338360.).

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