Reference intervals for routine biochemical markers and body mass index: A study based on healthcare center database in northeastern Iran

Hamideh Ghazizadeh(Mashhad University of Medical Sciences), Mahdiyeh Yaghooti‐Khorasani(Mashhad University of Medical Sciences), Atieh Kamel Khodabandeh(Mashhad University of Medical Sciences), Elahe Hasanzadeh(Mashhad University of Medical Sciences), Toktam Sahranavard(Islamic Azad University, Mashhad), Seyed Hamed Banihashem‐Rad(Mashhad University of Medical Sciences), Reza Zare‐Feyzabadi(Mashhad University of Medical Sciences), Mansoureh Sadat Ekhteraee‐Toosi(Islamic Azad University, Mashhad), Ensieh Akbarpour, Ameneh Timar(Mashhad University of Medical Sciences), Maryam Mohammadi‐Bajgiran(Mashhad University of Medical Sciences), Reza Assaran Darban(Islamic Azad University, Mashhad), Ehsan Mosa Farkhany(Mashhad University of Medical Sciences), Mohammad Reza Oladi(Mashhad University of Medical Sciences), Gordon A. Ferns(Brighton and Sussex Medical School), Habibollah Esmaily(Mashhad University of Medical Sciences), Majid Ghayour‐Mobarhan(Mashhad University of Medical Sciences)
IUBMB Life
December 31, 2020
10.1002/iub.2437
Cited by 23Open Access
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Abstract

Age- and sex-specific reference intervals (RIs) for some biochemical tests may be useful for their interpretation, due to the variations in lifestyle and genetic, or ethnic factors. The aim of this study was to obtain RIs for some routine biochemical markers including a serum lipid profile, fasting blood glucose (FBG), aspartate and alanine aminotransferase (AST and ALT), uric acid, and body mass index (BMI) in subjects who attended primary healthcare centers. The large database of primary healthcare centers uses RIs to report results for children, adolescents, and young and old adults. RIs were obtained by using the indirect method, recommended by the CLSI Ep28-A3 guidelines. RIs for FBG, BMI, and serum lipid profile, including triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in people aged 18 to 120 years, were obtained without age/sex segmentation. RIs for serum AST, ALT, and uric acid were obtained without age segmentation, though these RIs were higher in males than females. The RIs for AST, ALT, and uric acid were higher in men, while the RIs for the other variables were similar in both sexes. This is the first study reporting the use of indirect RIs for BMI.

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