Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic
Jeffrey R. Strich(United States Public Health Service Commissioned Officers Association), Marcos J. Ramos-Benítez(National Institutes of Health Clinical Center), Davide Randazzo(National Institutes of Health), Sydney Stein(National Institutes of Health Clinical Center), Ashley L. Babyak(National Institutes of Health Clinical Center), Richard T. Davey(National Institutes of Health), Anthony F. Suffredini(National Institutes of Health Clinical Center), Richard Childs(National Institutes of Health), Daniel S. Chertow(National Institutes of Health)
Cited by 111Open Access
Abstract
Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in coronavirus disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrated that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.
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