Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity
Patrick Ostkamp, Anke Salmen(University of Bern), Béatrice Pignolet(Centre National de la Recherche Scientifique), Dennis Görlich, Till F. M. Andlauer(Max Planck Institute of Psychiatry), Andreas Schulte‐Mecklenbeck, Gabriel González‐Escamilla(Johannes Gutenberg University Mainz), Florence Bucciarelli(Centre National de la Recherche Scientifique), Isabelle Gennero(Centre National de la Recherche Scientifique), Johanna Breuer, Gisela Antony(Philipps University of Marburg), Tilman Schneider‐Hohendorf, Nadine Mykicki(University of Münster), Antonios Bayas(University Hospital Augsburg), Florian Then Bergh(Leipzig University), Stefan Bittner(Johannes Gutenberg University Mainz), Hans‐Peter Hartung(Heinrich Heine University Düsseldorf), Manuel A. Friese(Universität Hamburg), Ralf A. Linker(University of Regensburg), Felix Luessi(Johannes Gutenberg University Mainz), Klaus Lehmann‐Horn(Munich Cluster for Systems Neurology), Mark Mühlau(Munich Cluster for Systems Neurology), Friedemann Paul(Max Delbrück Center), Martin Stangel(Medizinische Hochschule Hannover), Björn Tackenberg(Philipps University of Marburg), Hayrettin Tumani(Universität Ulm), Clemens Warnke(University Hospital Cologne), Frank Weber(Kliniken des Landkreises Lörrach), Brigitte Wildemann(Heidelberg University), Uwe K. Zettl(University of Rostock), Ulf Ziemann(University of Tübingen), Bertram Müller‐Myhsok(University of Liverpool), Tania Kümpfel(Munich Cluster for Systems Neurology), Luisa Klotz, Sven G. Meuth, Frauke Zipp(Johannes Gutenberg University Mainz), Bernhard Hemmer(Munich Cluster for Systems Neurology), Reinhard Hohlfeld(Munich Cluster for Systems Neurology), David Brassat(Centre National de la Recherche Scientifique), Ralf Gold(St. Josef-Hospital), Catharina C. Groß, Carsten Lukas(St. Josef-Hospital), Sergiu Groppa(Johannes Gutenberg University Mainz), Karin Loser(University of Münster), Heinz Wiendl, Nicholas Schwab, on behalf of the German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network(University Hospital Augsburg), Antonios Bayas(University Hospital Augsburg), Susanne Rothacher, Stephanie Starke(Max Delbrück Center), Friedemann Paul(Max Delbrück Center), Judith Bellmann–Strobl, Janina Behrens, Jan-Markus Dörr, René M. Gieß, Joseph Kuchling, Ludwig Rasche(St. Josef-Hospital), Ralf Gold(St. Josef-Hospital), Andrew T. Chan, Gisa Ellrichmann, Anna Lena Fisse, Anna Gahlen, Thomas Grüter, Aiden Haghikia, Robert Hoepner, U.-V. Koc(St. Josef-Hospital), Carsten Lukas(St. Josef-Hospital), Jeremias Motte, Kalliopi Pitarokoili(University of Bern), Anke Salmen(University of Bern), Ruth Schneider, Joanna Schöllhammer, Christoph Schroeder(Philipps University of Marburg), Björn Ambrosius, Seray Demir(Düsseldorf University Hospital), Clemens Warnke(University Hospital Cologne), Thomas Dehmel, Kathleen Ingenhoven(University of Regensburg), Ralf A. Linker(University of Regensburg), De-Hyung Lee, Alexandra Lämmer, Eva Sauer, Christoph Heesen, Jan‐Patrick Stellmann(Medizinische Hochschule Hannover), Martin Stangel(Medizinische Hochschule Hannover), Lena Boenig(Johannes Gutenberg University Mainz), Stefan Gingele(Medizinische Hochschule Hannover), Martin W. Hümmert, Philipp Schwenkenbecher, Thomas Skripuletz, Wolfram Suehs(Heidelberg University), Brigitte Wildemann(Heidelberg University), Mirjam Korporal‐Kuhnke, Hanna Oßwald, Alexander Schwarz, Andrea Viehöver, Volker Limmroth, Kathrin Gerbershagen(Leipzig University), Florian Then Bergh(Leipzig University), Barbara Ettrich, Steffi Gray, Sarah Haars, Johannes Orthgieß, Nicole Schwanitz, Muriel Stoppe, Astrid Unterlauft, Sandra Paryjas(Johannes Gutenberg University Mainz), Stefan Bittner(Johannes Gutenberg University Mainz), Vinzenz Fleischer(Johannes Gutenberg University Mainz), Sergiu Groppa(Johannes Gutenberg University Mainz), Felix Lüssi, Johannes Piepgras, Timo Uphaus(Philipps University of Marburg), Björn Tackenberg(Philipps University of Marburg), Michael Pütz, Christian Eienbröker, Maria Seipelt(Munich Cluster for Systems Neurology), Reinhard Hohlfeld(Munich Cluster for Systems Neurology), Tania Kümpfel(Munich Cluster for Systems Neurology), Joachim Havla, Ingrid Meinl, Hannah Pellkofer, Elisabeth Schuh(Munich Cluster for Systems Neurology), Bernhard Hemmer(Munich Cluster for Systems Neurology), Lilian Aly, Achim Berthele, Viola Pongratz, Kirsten Brinkhoff, Dorothea Buck, Christiane Gasperi, Mirjam Hermisson, Muna‐Miriam Hoshi, Miriam Kaminski, Ana Paula Klein, Benjamin Knier, Markus Kowarik, Helena Kronsbein(Munich Cluster for Systems Neurology), K Horn, Meike Mitsdörffer, Verena Pernpeintner, Veit Rothhammer, Andrea Schweikert, Rebecca Selter(Munich Cluster for Systems Neurology), Mark Mühlau(Munich Cluster for Systems Neurology), Claus Zimmer, Jan S. Kirschke(Kliniken des Landkreises Lörrach), Frank Weber(Kliniken des Landkreises Lörrach), Heike Staufer, Matthias Knop, Sandra Nischwitz, Philipp Sämann, Heinz Wiendl, Sven G. Meuth, Luisa Klotz, Gerd Meyer zu Hörste, Julia Krämer, Lena Schünemann, Catharina C. Groß, Steffen Pfeuffer, Tobias Ruck, Selma Belgriri, Alexander Buchheister, Nora Bünger, Kerstin Göbel, Lucienne Kirstein, Nico Melzer(Centre National de la Recherche Scientifique), Ole J. Simon, Antje K. C. Echterhoff(University of Rostock), Uwe K. Zettl(University of Rostock), Alexander Winkelmann(University of Tübingen), Ulf Ziemann(University of Tübingen), Ahmed Abdelhak, Markus Kowarik, Markus Krumbholz, Margarete Paech, Christoph Ruschil, Maria‐Ioanna Stefanou, Johannes Tünnerhoff, Lena Zeltner, Hajera Sheikh(Universität Ulm), Hayrettin Tumani(Universität Ulm), Tanja Fangerau(Leipzig University), Florian Lauda(Johannes Gutenberg University Mainz), Daniela Rau, Daniela Taranu, André Huss(Centre National de la Recherche Scientifique), David Brassat(Centre National de la Recherche Scientifique), Béatrice Pignolet(Centre National de la Recherche Scientifique), Florence Bucciarelli(Centre National de la Recherche Scientifique), Lise Scandella, Christine Lebrun-Frenay, Marc Debouverie, S. Pittion‐Vouyovitch, Bruno Brochet, Aurélie Ruet, Gilles Defer, Nathalie Derache, de Sèze(Centre National de la Recherche Scientifique), David Laplaud, Sandrine Wiertlewski, Oliver Casez, Pierre Clavelou, Pierre Labauge, Jean Pelletier, Audrey Rico, Sandra Vukusic, Olivier Outteryck, Jean-Claude, Jean‐Christophe Ouallet, Patrick Hautecoeur, Ayman Tourbah, Giovanni Castelnovo, Eric Berger, Hélène Zéphir, Philippe Cabre, William Camu, Éric Thouvenot, Thibault Moreau, Agnès Fromont, Caroline Papeix, Catherine Lubetzki, Patrick Vermersch, Mikaël Cohen, L. Rumbach
Cited by 73Open Access
Abstract
:rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests beneficial effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS.
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