M2 microglial small extracellular vesicles reduce glial scar formation <i>via</i> the miR-124/STAT3 pathway after ischemic stroke in mice
Zongwei Li(Shanghai Jiao Tong University), Yaying Song, Tingting He(Ruijin Hospital), Ruoxue Wen(Shanghai Sixth People's Hospital), Yong-Fang Li(Ruijin Hospital), Tingting Chen(Shanghai Sixth People's Hospital), Shuxian Huang(Shanghai Jiao Tong University), Yongting Wang(Shanghai Jiao Tong University), Yaohui Tang(Shanghai Sixth People's Hospital), Fanxia Shen(Shanghai Jiao Tong University), Heng‐Li Tian, Guo‐Yuan Yang(Shanghai Sixth People's Hospital), Zhijun Zhang(Shanghai Jiao Tong University)
Cited by 210Open Access
Abstract
Rationale: Glial scars present a major obstacle for neuronal regeneration after stroke. Thus, approaches to promote their degradation and inhibit their formation are beneficial for stroke recovery. The interaction of microglia and astrocytes is known to be involved in glial scar formation after stroke; however, how microglia affect glial scar formation remains unclear.
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