Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling

Hongda Li(Shanghai East Hospital), Yanfang Wang(Tongji University), Jiwen Liu(Shenzhen Ruipuxun Academy for Stem Cell & Regenerative Medicine), Xiaoli Chen(Tongji University), Yunhao Duan(Tongji University), Xiaoyu Wang(Tongji University), Yajing Shen(Tongji University), Yashu Kuang(Tongji University), Tao Zhuang(Shanghai East Hospital), B. Tomlinson(Macau University of Science and Technology), Paul Chan(Taipei Medical University), Zuoren Yu(Tongji University), Yu Cheng(Tongji University), Lin Zhang(Shanghai East Hospital), Zhongmin Liu(Shanghai East Hospital), Yuzhen Zhang(Tongji University), Zhenlin Zhao(Shenzhen Ruipuxun Academy for Stem Cell & Regenerative Medicine), Qi Zhang(Shanghai East Hospital), Jie Liu(Tongji University)
Theranostics
December 16, 2020
10.7150/thno.48153
Cited by 37Open Access
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Abstract

We conclude that cardiac microvasculature ECs are important in the modulation of pressure overload induced maladaptive cardiac remodeling and dysfunction, and the endothelial Klf2-TGFβ1 or Klf2-Foxp1-TGFβ1 pathway mediates the preventive effects of simvastatin. This study demonstrates a novel mechanism of the non-cholesterol lowering effects of simvastatin for HF prevention.

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