<i>Withdrawn:</i> L. Ma, T. Li, G. Liu, J. Wang, Z. Yin, J. Kang, LncRNA RHPN1‐AS1 modulates cholangiocarcinoma progression and is related with poor clinical outcomes through miR‐345‐5p/YAP1 axis

Abstract

LncRNAs have been reported to be involved in the initiation and progression of cholangiocarcinoma (CCA), although the mechanisms by which this occurs remains unknown. The current study aimed to reveal the clinico-pathological relationship of RHPN1-AS1 expressed with CCA, and also investigate the functions of RHPN1-AS1 both in vivo and in vitro. RHPN1-AS1 was overexpressed in CCA cell proliferation as well as promoted xenograft growth in vivo. Mechanistically, DANCR upregulated the expression of YAP1 by competitively binding to miR-345-5p. Importantly, RHPN1-AS1 level was positively correlated with YAP1 expression level in CCA tissues (P<0.05). Moreover, Kaplan-Meier curves showed that YAP1 overexpression predicted a poor outcome of CCA patients (P=0.004). Taken together, our results suggested that RHPN1-AS1 might be a remarkable biomarker to evaluate prognosis in CCA. The RHPN1-AS1/YAP1 axis may provide new strategies for CCA clinical practice.