Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells

Xinxin Yuan; Niansong Qian; Shukuan Ling; Yuheng Li; Weijia Sun; Jianwei Li; Ruikai Du; Guohui Zhong; Caizhi Liu; Guotao Yu; Dengchao Cao; Zizhong Liu; Yinbo Wang; Zhihong Qi; Yingpeng Yao; Fang Wang; Jingjing Liu; Shanshan Hao; Xiaoyan Jin; Yinlong Zhao; Jianqi Xue; Dingsheng Zhao; Xingcheng Gao; Shuai Liang; Youyou Li; Jinping Song; Shuyang Yu; Yingxian Li

doi:10.7150/thno.45351

Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells

Xinxin Yuan(China Astronaut Research and Training Center), Niansong Qian(Chinese PLA General Hospital), Shukuan Ling(China Astronaut Research and Training Center), Yuheng Li(China Astronaut Research and Training Center), Weijia Sun(China Astronaut Research and Training Center), Jianwei Li(China Astronaut Research and Training Center), Ruikai Du(China Astronaut Research and Training Center), Guohui Zhong(China Astronaut Research and Training Center), Caizhi Liu(China Astronaut Research and Training Center), Guotao Yu(China Agricultural University), Dengchao Cao(China Agricultural University), Zizhong Liu(China Astronaut Research and Training Center), Yinbo Wang(China Astronaut Research and Training Center), Zhihong Qi(China Agricultural University), Yingpeng Yao(China Agricultural University), Fang Wang(China Agricultural University), Jingjing Liu(China Agricultural University), Shanshan Hao(China Agricultural University), Xiaoyan Jin(China Astronaut Research and Training Center), Yinlong Zhao(China Astronaut Research and Training Center), Jianqi Xue(China Astronaut Research and Training Center), Dingsheng Zhao(China Astronaut Research and Training Center), Xingcheng Gao(China Astronaut Research and Training Center), Shuai Liang(China Astronaut Research and Training Center), Youyou Li(China Astronaut Research and Training Center), Jinping Song(China Astronaut Research and Training Center), Shuyang Yu(China Agricultural University), Yingxian Li(China Astronaut Research and Training Center)

Theranostics

December 16, 2020

10.7150/thno.45351

Cited by 310Open Access

Full Text

Abstract

Our results indicate that breast cancer cell-derived exosomes play an important role in promoting breast cancer bone metastasis, which is associated with the formation of pre-metastatic niche via transferring miR-21 to osteoclasts. The data from patient samples further reflect the significance of miR-21 as a potential target for clinical diagnosis and treatment of breast cancer bone metastasis.

Related Papers

No related papers found

Powered by citation graph analysis