Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders
Jian Yang(Capital Medical University), Peng Zheng(The Affiliated Yongchuan Hospital of Chongqing Medical University), Yifan Li(The Affiliated Yongchuan Hospital of Chongqing Medical University), Jing Wu(The Affiliated Yongchuan Hospital of Chongqing Medical University), Xunmin Tan(The Affiliated Yongchuan Hospital of Chongqing Medical University), Jingjing Zhou(Capital Medical University), Zuoli Sun(Capital Medical University), Xu Chen(Capital Medical University), Guofu Zhang(Capital Medical University), Hanping Zhang(The Affiliated Yongchuan Hospital of Chongqing Medical University), Yu Huang(The Affiliated Yongchuan Hospital of Chongqing Medical University), Tingjia Chai(The Affiliated Yongchuan Hospital of Chongqing Medical University), Jiajia Duan(The Affiliated Yongchuan Hospital of Chongqing Medical University), Weiwei Liang(The Affiliated Yongchuan Hospital of Chongqing Medical University), Bangmin Yin(The Affiliated Yongchuan Hospital of Chongqing Medical University), Jianbo Lai(First Affiliated Hospital Zhejiang University), Tingting Huang(Zhejiang University), Yanli Du(Zhejiang University), Peifen Zhang(Zhejiang University), Jiajun Jiang(Zhejiang University), Caixi Xi(Zhejiang University), Lingling Wu(Zhejiang University), Jing Lü(First Affiliated Hospital Zhejiang University), Tingting Mou(First Affiliated Hospital Zhejiang University), Yi Xu(First Affiliated Hospital Zhejiang University), Seth W. Perry(SUNY Upstate Medical University), Ma‐Li Wong(SUNY Upstate Medical University), Júlio Licinio(SUNY Upstate Medical University), Shaohua Hu(First Affiliated Hospital Zhejiang University), Gang Wang(Capital Medical University), Peng Xie(The Affiliated Yongchuan Hospital of Chongqing Medical University)
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Abstract
These multilevel omics alterations generated a characteristic MDD coexpression network. Disturbed microbial genes and fecal metabolites were consistently mapped to amino acid (γ-aminobutyrate, phenylalanine, and tryptophan) metabolism. Furthermore, we identified a combinatorial marker panel that robustly discriminated MDD from HC individuals in both the discovery and validation sets. Our findings provide a deep insight into understanding of the roles of disturbed gut ecosystem in MDD.
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