Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis
Olivier Govaere(Newcastle University), Simon Cockell(Newcastle University), Dina Tiniakos(National and Kapodistrian University of Athens), Rachel Queen(Newcastle University), Ramy Younes(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Michèle Vacca(University of Cambridge), Leigh Alexander(SomaLogic (United States)), Federico Ravaioli(Newcastle University), Jeremy M. Palmer(Newcastle University), Salvatore Petta(University of Palermo), Jérôme Boursier(Université d'Angers), Chiara Rosso(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Katherine Johnson(Newcastle University), Kristy Wonders(Newcastle University), Christopher P. Day(Newcastle University), Mattias Ekstedt(Linköping University), Matej Orešič(Örebro University), Rebecca Darlay(Newcastle University), Heather J. Cordell(Newcastle University), Fabio Marra(University of Florence), Antonio Vidal‐Puig(University of Cambridge), Pierre Bédossa(Sorbonne Université), Jörn M. Schattenberg(University of Applied Sciences Mainz), Karine Clément(Inserm), Michael Allison(Cambridge University Hospitals NHS Foundation Trust), Elisabetta Bugianesi(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Vlad Ratziu(Sorbonne Université), Ann K. Daly(Newcastle University), Quentin M. Anstee(Newcastle upon Tyne Hospital)
Cited by 447Open Access
Abstract
, whereas GDF15 supplementation tempered the inflammatory response in macrophages upon lipid loading and lipopolysaccharide stimulation. This study provides insights into the pathophysiology of progressive fibrosing steatohepatitis, and proof of principle that transcriptomic changes represent potentially tractable and clinically relevant markers of disease progression.
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