Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis
Tripp Leavitt(California Institute for Regenerative Medicine), Michael S. Hu(California Institute for Regenerative Medicine), Mimi R. Borrelli(California Institute for Regenerative Medicine), Michael Januszyk(California Institute for Regenerative Medicine), Julia T. Garcia(Stanford University), Ryan C. Ransom(California Institute for Regenerative Medicine), Shamik Mascharak(California Institute for Regenerative Medicine), Heather E. desJardins-Park(California Institute for Regenerative Medicine), Ulrike Litzenburger(California Institute for Regenerative Medicine), Graham G. Walmsley(California Institute for Regenerative Medicine), Clement D. Marshall(California Institute for Regenerative Medicine), Alessandra L. Moore(California Institute for Regenerative Medicine), Bryan Duoto(California Institute for Regenerative Medicine), Sandeep Adem(California Institute for Regenerative Medicine), Deshka S. Foster(California Institute for Regenerative Medicine), Ankit Salhotra(Stanford University), Abra H. Shen(California Institute for Regenerative Medicine), Michelle Griffin(California Institute for Regenerative Medicine), Ethan Shen(California Institute for Regenerative Medicine), Leandra A. Barnes(California Institute for Regenerative Medicine), Elizabeth R. Zielins(California Institute for Regenerative Medicine), Zeshaan N. Maan(Stanford University), Yuning Wei(California Institute for Regenerative Medicine), Charles K. F. Chan(California Institute for Regenerative Medicine), Derrick C. Wan(California Institute for Regenerative Medicine), H. Peter Lorenz(Stanford University), Howard Y. Chang(Howard Hughes Medical Institute), Geoffrey C. Gurtner(California Institute for Regenerative Medicine), Michael T. Longaker(California Institute for Regenerative Medicine)
Cited by 81Open Access
Abstract
Fibroblast heterogeneity has been shown within the unwounded mouse dorsal dermis, with fibroblast subpopulations being identified according to anatomical location and embryonic lineage. Using lineage tracing, we demonstrate that paired related homeobox 1 (Prrx1)-expressing fibroblasts are responsible for acute and chronic fibroses in the ventral dermis. Single-cell transcriptomics further corroborated the inherent fibrotic characteristics of Prrx1 fibroblasts during wound repair. In summary, we identify and characterize a fibroblast subpopulation in the mouse ventral dermis with intrinsic scar-forming potential.
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