Central Nervous System Cancers, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology
Burt Nabors(University of Colorado Cancer Center), Jana Portnow(City Of Hope National Medical Center), Manmeet S. Ahluwalia(Cleveland Clinic), Joachim M. Baehring(Smilow Cancer Hospital), Henry Brem(Sidney Kimmel Comprehensive Cancer Center), Steven Brem(University of Pennsylvania), Nicholas Butowski(UCSF Helen Diller Family Comprehensive Cancer Center), Jian Campian(Barnes-Jewish Hospital), Stephen W. Clark(Roswell Park Comprehensive Cancer Center), Andrew J. Fabiano, Peter Forsyth(Moffitt Cancer Center), Jona A. Hattangadi‐Gluth(University of California San Diego), Matthias Holdhoff(Sidney Kimmel Comprehensive Cancer Center), Craig Horbinski(Robert H. Lurie Comprehensive Cancer Center of Northwestern University), Larry Junck(University of Michigan), Thomas Kaley(Memorial Sloan Kettering Cancer Center), Priya Kumthekar(Robert H. Lurie Comprehensive Cancer Center of Northwestern University), Jay S. Loeffler(Massachusetts General Hospital), Maciej M. Mrugała(Cancer Clinic), Seema Nagpal(Cancer Institute (WIA)), Manjari Pandey(St. Jude Children's Research Hospital), Ian F. Parney(Cancer Clinic), Katherine B. Peters(Cancer Institute (WIA)), Vinay K. Puduvalli(The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute), Ian Robins(University of Wisconsin Carbone Cancer Center), Jason K. Rockhill(Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa), Chad G. Rusthoven(University of Colorado Cancer Center), Nicole Shonka(Susan Thompson Buffett Foundation), Dennis C. Shrieve(University of Utah), Lode J. Swinnen(Sidney Kimmel Comprehensive Cancer Center), Stephanie E. Weiss(Fox Chase Cancer Center), Patrick Y. Wen(Dana-Farber Cancer Institute), Nicole E. Willmarth(American Brain Tumor Association), Mary Anne Bergman(National Comprehensive Cancer Network), Susan Darlow(National Comprehensive Cancer Network)
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Abstract
The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of adult CNS cancers ranging from noninvasive and surgically curable pilocytic astrocytomas to metastatic brain disease. The involvement of an interdisciplinary team, including neurosurgeons, radiation therapists, oncologists, neurologists, and neuroradiologists, is a key factor in the appropriate management of CNS cancers. Integrated histopathologic and molecular characterization of brain tumors such as gliomas should be standard practice. This article describes NCCN Guidelines recommendations for WHO grade I, II, III, and IV gliomas. Treatment of brain metastases, the most common intracranial tumors in adults, is also described.
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