Unresectable Chondrosarcomas Treated With Carbon Ion Radiotherapy: Relationship Between Dose-averaged Linear Energy Transfer and Local Recurrence

Shinnosuke Matsumoto(National Institutes for Quantum and Radiological Science and Technology), Sung Hyun Lee(National Institutes for Quantum and Radiological Science and Technology), Reiko Imai(National Institutes for Quantum and Radiological Science and Technology), Taku Inaniwa(National Institutes for Quantum and Radiological Science and Technology), Naruhiro Matsufuji(National Institutes for Quantum and Radiological Science and Technology), Mai Fukahori(National Institutes for Quantum and Radiological Science and Technology), Ryosuke Kohno(National Institutes for Quantum and Radiological Science and Technology), Shunsuke Yonai(National Institutes for Quantum and Radiological Science and Technology), Noriyuki Okonogi(National Institutes for Quantum and Radiological Science and Technology), Shigeru Yamada(National Institutes for Quantum and Radiological Science and Technology), Nobuyuki Kanematsu(National Institutes for Quantum and Radiological Science and Technology)
Anticancer Research
October 27, 2020
10.21873/anticanres.14664
Cited by 51Open Access
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Abstract

BACKGROUND/AIM: The local control rate of chondrosarcomas treated with carbon-ion radiotherapy (CIRT) worsens as tumour size increases, possibly because of the intra-tumoural linear energy transfer (LET) distribution. This study aimed to evaluate the relationship between local recurrence and intra-tumoural LET distribution in chondrosarcomas treated with CIRT. PATIENTS AND METHODS: distribution in the planning tumour volume (PTV) and local control was evaluated. RESULTS: value exceeded 40 keV/μm. CONCLUSION: may have an improved local control rate for unresectable chondrosarcomas.

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