Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

Erik L. Bao; Satish K. Nandakumar; Xiaotian Liao; Alexander G. Bick; Juha Karjalainen; Marcin Tabaka; Olga I. Gan; Aki S. Havulinna; Tuomo Kiiskinen; Caleb A. Lareau; Aitzkoa Lopez de Lapuente Portilla; Bo Li; Connor A. Emdin; Veryan Codd; Christopher P. Nelson; Christopher J. Walker; Claire Churchhouse; Albert de la Chapelle; Daryl E. Klein; Björn Nilsson; Peter W.F. Wilson; Kelly Cho; Saiju Pyarajan; J. Michael Gaziano; Nilesh J. Samani; FinnGen; Aarno Palotie; Mark J. Daly; Pharmaceutical companies; Howard J. Jacob; Athena Matakidou; Heiko Runz; Sally John; Robert M. Plenge; Mark I. McCarthy; Julie Hunkapiller; Meg Ehm; Dawn Waterworth; Caroline S. Fox; Anders Mälarstig; Kathy Klinger; Kathy Call; Tomi P. Mäkelä; Jaakko Kaprio; Petri Virolainen; Kari Pulkki; Terhi Kilpi; Markus Perola; Jukka Partanen; Anne Pitkäranta; Riitta Kaarteenaho; Seppo Vainio; Kimmo Savinainen; Veli‐Matti Kosma; Urho M. Kujala; Other experts and non-voting members; Outi Tuovila; Minna Hendolin; Raimo Pakkanen; Pharmaceutical companies; Jeff Waring; Bridget Riley‐Gillis; Athena Matakidou; Heiko Runz; Jimmy Z. Liu; Shameek Biswas; Julie Hunkapiller; Dawn Waterworth; Meg Ehm; Dorothée Diogo; Caroline S. Fox; Anders Mälarstig; Catherine Marshall; Xinli Hu; Kathy Call; Kathy Klinger; Matthias Gossel; Samuli Ripatti; Johanna Schleutker; Markus Perola; Mikko Arvas; Olli Carpén; Reetta Hinttala; Johannes Kettunen; Reijo Laaksonen; Arto Mannermaa; Urho M. Kujala; Other experts and non-voting members; Outi Tuovila; Minna Hendolin; Raimo Pakkanen; Neurology group; Hilkka Soininen; Valtteri Julkunen; Anne M. Remes; Reetta Kälviäinen; Mikko Hiltunen; Jukka Peltola; Pentti J. Tienari; Juha O. Rinne; Adam Ziemann; Jeffrey Waring; Sahar Esmaeeli; Nizar Smaoui; Anne Lehtonen; Susan Eaton; Heiko Runz; Sanni Lahdenperä; Janet van Adelsberg; Shameek Biswas; John Michon; Geoff Kerchner; Julie Hunkapiller; Natalie Bowers; Edmond Teng; John D. Eicher; Vinay Mehta; Padhraig Gormley; Kari Linden; Christopher D. Whelan; Fanli Xu; David Pulford; Gastroenterology group; Martti Färkkilâ; Sampsa Pikkarainen; Airi Jussila; Timo Blomster; Mikko Kiviniemi; Markku Voutilainen; Bob Georgantas; Graham Heap; Jeffrey F. Waring; Nizar Smaoui; Fedik Rahimov; Anne Lehtonen; Keith Usiskin; Joseph Maranville; Tim Lu; Natalie Bowers; Danny Oh; John Michon; Vinay Mehta; Kirsi Kalpala; Melissa Miller; Xinli Hu; Linda McCarthy; Rheumatology group; Kari K. Eklund; Antti Palomäki; Pia Isomäki; Laura Pirilä; Oili Kaipiainen‐Seppänen; Johanna Huhtakangas; Bob Georgantas; Jeffrey F. Waring; Fedik Rahimov; Apinya Lertratanakul; Nizar Smaoui; Anne Lehtonen; David A. Close; Marla Hochfeld; Natalie Bowers; John Michon; Dorothée Diogo; Vinay Mehta; Kirsi Kalpala; Nan Bing; Xinli Hu; Jorge Esparza Gordillo; Nina Mars; Pulmonology group; Tarja Laitinen; Margit Pelkonen; Paula Kauppi; Hannu Kankaanranta; Terttu Harju; Nizar Smaoui; David A. Close; Steven M. Greenberg; Hubert Chen; Natalie Bowers; John Michon; Vinay Mehta; Jo Betts; Soumitra Ghosh; Cardiometabolic diseases group; Veikko Salomaa; Teemu Niiranen; Markus Juonala; Kaj Metsärinne; Mika Kähönen; Juhani Junttila; Markku Laakso; Jussi Pihlajamäki; Juha Sinisalo; Marja‐Riitta Taskinen; Tiinamaija Tuomi; Jari A. Laukkanen; Ben Challis; Andrew S. Peterson; Julie Hunkapiller; Natalie Bowers; John A. Michon; Dorothée Diogo; Audrey Y. Chu; Vinay Mehta; Jaakko Parkkinen; Melissa Miller; Anthony J. Muslin; Dawn Waterworth; Oncology group; Heikki Joensuu; Tuomo J Meretoja; Olli Carpén; Lauri A. Aaltonen; Annika Auranen; Peeter Karihtala; Saila Kauppila; Päivi Auvinen; Klaus Elenius; Relja Popovic; Jeffrey Waring; Bridget Riley‐Gillis; Anne Lehtonen; Athena Matakidou; Jennifer L. Schutzman; Julie Hunkapiller; Natalie Bowers; John Michon; Vinay Mehta; Andrey Loboda; Aparna Chhibber; Heli Lehtonen; Stefan McDonough; Marika Crohns; Diptee Kulkarni; Opthalmology group; Kai Kaarniranta; Joni A. Turunen; Terhi Ollila; Sanna Seitsonen; Hannu Uusitalo; Vesa Aaltonen; Hannele Uusitalo‐Järvinen; Marja Luodonpää; Nina Hautala; Heiko Runz; Erich C. Strauss; Natalie Bowers; Hao Chen; John Michon; Anna Podgornaia; Vinay Mehta; Dorothee Diogo; Joshua Hoffman; Dermatology group; Kaisa Tasanen; Laura Huilaja; Katariina Hannula‐Jouppi; Teea Salmi; Sirkku Peltonen; Leena Koulu; Ilkka T. Harvima; Kirsi Kalpala; Ying Wu; David F. Choy; John A. Michon; Nizar Smaoui; Fedik Rahimov; Anne Lehtonen; Dawn Waterworth; FinnGen analysis working group; J. Wade Davis; Bridget Riley‐Gillis; Danjuma Quarless; Slavé Petrovski; Jimmy Z. Liu; Chia‐Yen Chen; Paola G. Bronson; Robert Yang; Joseph Maranville; Shameek Biswas; Diana Chang; Julie Hunkapiller; Tushar Bhangale; Natalie Bowers; Dorothee Diogo; Emily Holzinger; Padhraig Gormley; Xulong Wang; Xing Chen; Åsa K. Hedman; Kirsi Auro; Clarence Wang; Ethan Xu; Franck Augé; Clément Chatelain; Mitja Kurki; Samuli Ripatti; Mark J. Daly; Juha Karjalainen; Aki S. Havulinna; Anu Jalanko; Kimmo Palin; Priit Palta; Pietro Della Briotta Parolo; Wei Zhou; Susanna Lemmelä; Manuel A. Rivas; Jarmo Harju; Aarno Palotie; Arto Lehistö; Andrea Ganna; Vincent Llorens; Antti Karlsson; Kati Kristiansson; Mikko Arvas; Kati Hyvärinen; Jarmo Ritari; Tiina Wahlfors; Miika Koskinen; Olli Carpén; Johannes Kettunen; Katri Pylkäs; Marita Kalaoja; Minna K. Karjalainen; Tuomo Mantere; Eeva Kangasniemi; Sami Heikkinen; Arto Mannermaa; Eija K. Laakkonen; Juha Kononen; Biobank directors; Lila Kallio; Sirpa Soini; Jukka Partanen; Kimmo Pitkänen; Seppo Vainio; Kimmo Savinainen; Veli‐Matti Kosma; Teijo Kuopio; FinnGen team; Administration; Anu Jalanko; Risto Kajanne; Ulrike Lyhs; Analysis; Mitja Kurki; Juha Karjalainen; Pietro della Briotta Parola; Sina Rüeger; Arto Lehistö; Wei Zhou; Masahiro Kanai; Hannele Laivuori; Aki S. Havulinna; Susanna Lemmelä; Tuomo Kiiskinen; Communication; Mari Kaunisto; Data management and IT infrastructure; Jarmo Harju; Elina Kilpeläinen; Timo P. Sipilä; Georg Brein; Oluwaseun Alexander Dada; Awaisa Ghazal; Anastasia Shcherban; Tuomas Sipilä; Genotyping; Kati Donner; Sample collection coordination; Anu Loukola; Sample logistics; Päivi Laiho; Tuuli Sistonen; Essi Kaiharju; Markku Laukkanen; Elina Järvensivu; Sini Lähteenmäki; Lotta Männikkö; Regis Wong; Registry data operations; Hannele Mattsson; Kati Kristiansson; Susanna Lemmelä; Tero Hiekkalinna; Manuel González Jiménez; Sequencing informatics; Priit Palta; Kalle Pärn; Javier Núñez-Fontarnau; Trajectory team; Tarja Laitinen; Harri Siirtola; Javier Gracia‐Tabuenca; Michelle Agee; Babak Alipanahi; Adam Auton; Robert K. Bell; Katarzyna Bryc; Sarah L. Elson; Pierre Fontanillas; Nicholas A. Furlotte; David A. Hinds; Karen E. Huber; Aaron Kleinman; Nadia K. Litterman; Jennifer C. McCreight; Matthew H. McIntyre; Joanna L. Mountain; Elizabeth S. Noblin; Carrie A. M. Northover; Steven J. Pitts; J. Fah Sathirapongsasuti; Olga V. Sazonova; Janie F. Shelton; Suyash Shringarpure; Chao Tian; Joyce Y. Tung; Vladimir Vacic; Catherine H. Wilson; Aviv Regev; Aarno Palotie; Benjamin M. Neale; John E. Dick; Pradeep Natarajan; Christopher J. O’Donnell; Mark J. Daly; Michael Milyavsky; Sekar Kathiresan; Vijay G. Sankaran

doi:10.1038/s41586-020-2786-7

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

Erik L. Bao(Broad Institute), Satish K. Nandakumar(Broad Institute), Xiaotian Liao(Broad Institute), Alexander G. Bick(Broad Institute), Juha Karjalainen(Broad Institute), Marcin Tabaka(Broad Institute), Olga I. Gan(University Health Network), Aki S. Havulinna(University of Helsinki), Tuomo Kiiskinen(University of Helsinki), Caleb A. Lareau(Broad Institute), Aitzkoa Lopez de Lapuente Portilla(Lund University), Bo Li(Broad Institute), Connor A. Emdin(Broad Institute), Veryan Codd(Glenfield Hospital), Christopher P. Nelson(Glenfield Hospital), Christopher J. Walker(The Ohio State University), Claire Churchhouse(Broad Institute), Albert de la Chapelle(The Ohio State University), Daryl E. Klein(Yale Cancer Center), Björn Nilsson(Broad Institute), Peter W.F. Wilson(Emory Healthcare), Kelly Cho(Brigham and Women's Hospital), Saiju Pyarajan(VA Boston Healthcare System), J. Michael Gaziano(Brigham and Women's Hospital), Nilesh J. Samani(Glenfield Hospital), FinnGen(Broad Institute), Aarno Palotie(Broad Institute), Mark J. Daly(Broad Institute), Pharmaceutical companies(AstraZeneca (United Kingdom)), Howard J. Jacob(Biogen (United States)), Athena Matakidou(Biogen (United States)), Heiko Runz, Sally John, Robert M. Plenge, Mark I. McCarthy(GlaxoSmithKline (United Kingdom)), Julie Hunkapiller(GlaxoSmithKline (United Kingdom)), Meg Ehm(Merck & Co., Inc., Rahway, NJ, USA (United States)), Dawn Waterworth(Pfizer (United States)), Caroline S. Fox(Sanofi (France)), Anders Mälarstig(Sanofi (France)), Kathy Klinger(University of Helsinki), Kathy Call(University of Helsinki), Tomi P. Mäkelä(University of Turku), Jaakko Kaprio(University of Turku), Petri Virolainen(Finnish Institute for Health and Welfare), Kari Pulkki(Finnish Institute for Health and Welfare), Terhi Kilpi(Finnish Red Cross), Markus Perola(Hospital District of Helsinki and Uusimaa), Jukka Partanen(Borealis (Finland)), Anne Pitkäranta(Borealis (Finland)), Riitta Kaarteenaho(Tampere University), Seppo Vainio(University of Eastern Finland), Kimmo Savinainen(Central Finland Health Care District), Veli‐Matti Kosma(Business Finland), Urho M. Kujala(Business Finland), Other experts and non-voting members(Business Finland), Outi Tuovila(AbbVie (United States)), Minna Hendolin(AbbVie (United States)), Raimo Pakkanen(AstraZeneca (United Kingdom)), Pharmaceutical companies(Biogen (United States)), Jeff Waring(Biogen (United States)), Bridget Riley‐Gillis, Athena Matakidou, Heiko Runz(GlaxoSmithKline (United Kingdom)), Jimmy Z. Liu(GlaxoSmithKline (United Kingdom)), Shameek Biswas(Merck & Co., Inc., Rahway, NJ, USA (United States)), Julie Hunkapiller(Merck & Co., Inc., Rahway, NJ, USA (United States)), Dawn Waterworth(Pfizer (United States)), Meg Ehm(Pfizer (United States)), Dorothée Diogo(Pfizer (United States)), Caroline S. Fox(Sanofi (France)), Anders Mälarstig(Sanofi (France)), Catherine Marshall(Sanofi (France)), Xinli Hu(University of Helsinki), Kathy Call(University of Turku), Kathy Klinger(Finnish Institute for Health and Welfare), Matthias Gossel(Finnish Red Cross), Samuli Ripatti(Hospital District of Helsinki and Uusimaa), Johanna Schleutker(Borealis (Finland)), Markus Perola(Borealis (Finland)), Mikko Arvas(Tampere University), Olli Carpén(University of Eastern Finland), Reetta Hinttala(Central Finland Health Care District), Johannes Kettunen(Business Finland), Reijo Laaksonen(Business Finland), Arto Mannermaa(Business Finland), Urho M. Kujala, Other experts and non-voting members, Outi Tuovila(Northern Ostrobothnia Hospital District), Minna Hendolin, Raimo Pakkanen, Neurology group(Pirkanmaa Hospital District), Hilkka Soininen(Hospital District of Helsinki and Uusimaa), Valtteri Julkunen(Varsinais-Suomen Sairaanhoitopiiri), Anne M. Remes(AbbVie (United States)), Reetta Kälviäinen(AbbVie (United States)), Mikko Hiltunen(AbbVie (United States)), Jukka Peltola(AbbVie (United States)), Pentti J. Tienari(AbbVie (United States)), Juha O. Rinne(Biogen (United States)), Adam Ziemann(Biogen (United States)), Jeffrey Waring(Biogen (United States)), Sahar Esmaeeli, Nizar Smaoui, Anne Lehtonen, Susan Eaton, Heiko Runz, Sanni Lahdenperä, Janet van Adelsberg, Shameek Biswas(Merck & Co., Inc., Rahway, NJ, USA (United States)), John Michon(GlaxoSmithKline (United Kingdom)), Geoff Kerchner(Merck & Co., Inc., Rahway, NJ, USA (United States)), Julie Hunkapiller(Pfizer (United States)), Natalie Bowers(Pfizer (United States)), Edmond Teng(GlaxoSmithKline (United Kingdom)), John D. Eicher(GlaxoSmithKline (United Kingdom)), Vinay Mehta(Hospital District of Helsinki and Uusimaa), Padhraig Gormley(Hospital District of Helsinki and Uusimaa), Kari Linden(Pirkanmaa Hospital District), Christopher D. Whelan(Northern Ostrobothnia Hospital District), Fanli Xu, David Pulford(Varsinais-Suomen Sairaanhoitopiiri), Gastroenterology group(AbbVie (United States)), Martti Färkkilâ(AbbVie (United States)), Sampsa Pikkarainen(AbbVie (United States)), Airi Jussila(AbbVie (United States)), Timo Blomster(AbbVie (United States)), Mikko Kiviniemi(AbbVie (United States)), Markku Voutilainen, Bob Georgantas, Graham Heap, Jeffrey F. Waring, Nizar Smaoui, Fedik Rahimov, Anne Lehtonen(GlaxoSmithKline (United Kingdom)), Keith Usiskin(Pfizer (United States)), Joseph Maranville(Pfizer (United States)), Tim Lu(Pfizer (United States)), Natalie Bowers(GlaxoSmithKline (United Kingdom)), Danny Oh(Hospital District of Helsinki and Uusimaa), John Michon(Varsinais-Suomen Sairaanhoitopiiri), Vinay Mehta(Pirkanmaa Hospital District), Kirsi Kalpala(Varsinais-Suomen Sairaanhoitopiiri), Melissa Miller, Xinli Hu(Northern Ostrobothnia Hospital District), Linda McCarthy(AbbVie (United States)), Rheumatology group(AbbVie (United States)), Kari K. Eklund(AbbVie (United States)), Antti Palomäki(AbbVie (United States)), Pia Isomäki(AbbVie (United States)), Laura Pirilä(AbbVie (United States)), Oili Kaipiainen‐Seppänen(AstraZeneca (United Kingdom)), Johanna Huhtakangas, Bob Georgantas, Jeffrey F. Waring, Fedik Rahimov(Merck & Co., Inc., Rahway, NJ, USA (United States)), Apinya Lertratanakul(GlaxoSmithKline (United Kingdom)), Nizar Smaoui(Pfizer (United States)), Anne Lehtonen(Pfizer (United States)), David A. Close(Pfizer (United States)), Marla Hochfeld(GlaxoSmithKline (United Kingdom)), Natalie Bowers(University of Helsinki), John Michon, Dorothée Diogo(Hospital District of Helsinki and Uusimaa), Vinay Mehta(Pirkanmaa Hospital District), Kirsi Kalpala(Northern Ostrobothnia Hospital District), Nan Bing(AbbVie (United States)), Xinli Hu(AstraZeneca (United Kingdom)), Jorge Esparza Gordillo, Nina Mars, Pulmonology group, Tarja Laitinen, Margit Pelkonen(Merck & Co., Inc., Rahway, NJ, USA (United States)), Paula Kauppi(GlaxoSmithKline (United Kingdom)), Hannu Kankaanranta(GlaxoSmithKline (United Kingdom)), Terttu Harju(Finnish Institute for Health and Welfare), Nizar Smaoui(Finnish Institute for Health and Welfare), David A. Close(Varsinais-Suomen Sairaanhoitopiiri), Steven M. Greenberg(Varsinais-Suomen Sairaanhoitopiiri), Hubert Chen(Pirkanmaa Hospital District), Natalie Bowers(Northern Ostrobothnia Hospital District), John Michon, Vinay Mehta, Jo Betts(Hospital District of Helsinki and Uusimaa), Soumitra Ghosh(Hospital District of Helsinki and Uusimaa), Cardiometabolic diseases group(Hospital District of Helsinki and Uusimaa), Veikko Salomaa(Central Finland Health Care District), Teemu Niiranen(AstraZeneca (United Kingdom)), Markus Juonala, Kaj Metsärinne, Mika Kähönen, Juhani Junttila, Markku Laakso(Merck & Co., Inc., Rahway, NJ, USA (United States)), Jussi Pihlajamäki(Merck & Co., Inc., Rahway, NJ, USA (United States)), Juha Sinisalo(Merck & Co., Inc., Rahway, NJ, USA (United States)), Marja‐Riitta Taskinen(Pfizer (United States)), Tiinamaija Tuomi(Pfizer (United States)), Jari A. Laukkanen(Sanofi (France)), Ben Challis(GlaxoSmithKline (United Kingdom)), Andrew S. Peterson(Hospital District of Helsinki and Uusimaa), Julie Hunkapiller(Hospital District of Helsinki and Uusimaa), Natalie Bowers(Hospital District of Helsinki and Uusimaa), John A. Michon(Hospital District of Helsinki and Uusimaa), Dorothée Diogo(Pirkanmaa Hospital District), Audrey Y. Chu(Northern Ostrobothnia Hospital District), Vinay Mehta(Northern Ostrobothnia Hospital District), Jaakko Parkkinen, Melissa Miller(Varsinais-Suomen Sairaanhoitopiiri), Anthony J. Muslin(AbbVie (United States)), Dawn Waterworth(AbbVie (United States)), Oncology group(AbbVie (United States)), Heikki Joensuu(AbbVie (United States)), Tuomo J Meretoja(AstraZeneca (United Kingdom)), Olli Carpén, Lauri A. Aaltonen, Annika Auranen, Peeter Karihtala, Saila Kauppila(Merck & Co., Inc., Rahway, NJ, USA (United States)), Päivi Auvinen(Merck & Co., Inc., Rahway, NJ, USA (United States)), Klaus Elenius(Merck & Co., Inc., Rahway, NJ, USA (United States)), Relja Popovic(Pfizer (United States)), Jeffrey Waring(Pfizer (United States)), Bridget Riley‐Gillis(Sanofi (France)), Anne Lehtonen(GlaxoSmithKline (United Kingdom)), Athena Matakidou, Jennifer L. Schutzman(Hospital District of Helsinki and Uusimaa), Julie Hunkapiller(Hospital District of Helsinki and Uusimaa), Natalie Bowers(Hospital District of Helsinki and Uusimaa), John Michon(Pirkanmaa Hospital District), Vinay Mehta(Varsinais-Suomen Sairaanhoitopiiri), Andrey Loboda(Pirkanmaa Hospital District), Aparna Chhibber(Northern Ostrobothnia Hospital District), Heli Lehtonen(Northern Ostrobothnia Hospital District), Stefan McDonough(Biogen (United States)), Marika Crohns, Diptee Kulkarni, Opthalmology group, Kai Kaarniranta, Joni A. Turunen(Merck & Co., Inc., Rahway, NJ, USA (United States)), Terhi Ollila(Merck & Co., Inc., Rahway, NJ, USA (United States)), Sanna Seitsonen(Merck & Co., Inc., Rahway, NJ, USA (United States)), Hannu Uusitalo(GlaxoSmithKline (United Kingdom)), Vesa Aaltonen(Northern Ostrobothnia Hospital District), Hannele Uusitalo‐Järvinen(Northern Ostrobothnia Hospital District), Marja Luodonpää(Hospital District of Helsinki and Uusimaa), Nina Hautala(Pirkanmaa Hospital District), Heiko Runz(Varsinais-Suomen Sairaanhoitopiiri), Erich C. Strauss(Varsinais-Suomen Sairaanhoitopiiri), Natalie Bowers, Hao Chen(Pfizer (United States)), John Michon(Pfizer (United States)), Anna Podgornaia, Vinay Mehta, Dorothee Diogo(AbbVie (United States)), Joshua Hoffman(AbbVie (United States)), Dermatology group(AbbVie (United States)), Kaisa Tasanen(GlaxoSmithKline (United Kingdom)), Laura Huilaja(AbbVie (United States)), Katariina Hannula‐Jouppi(AbbVie (United States)), Teea Salmi(AbbVie (United States)), Sirkku Peltonen(AstraZeneca (United Kingdom)), Leena Koulu(Biogen (United States)), Ilkka T. Harvima(Biogen (United States)), Kirsi Kalpala(Biogen (United States)), Ying Wu, David F. Choy, John A. Michon, Nizar Smaoui, Fedik Rahimov, Anne Lehtonen, Dawn Waterworth, FinnGen analysis working group(Merck & Co., Inc., Rahway, NJ, USA (United States)), J. Wade Davis(Merck & Co., Inc., Rahway, NJ, USA (United States)), Bridget Riley‐Gillis(Merck & Co., Inc., Rahway, NJ, USA (United States)), Danjuma Quarless(Merck & Co., Inc., Rahway, NJ, USA (United States)), Slavé Petrovski(Pfizer (United States)), Jimmy Z. Liu(Pfizer (United States)), Chia‐Yen Chen(GlaxoSmithKline (United Kingdom)), Paola G. Bronson(Sanofi (France)), Robert Yang(Sanofi (France)), Joseph Maranville(Sanofi (France)), Shameek Biswas(Sanofi (France)), Diana Chang(University of Helsinki), Julie Hunkapiller(University of Helsinki), Tushar Bhangale(University of Helsinki), Natalie Bowers(University of Helsinki), Dorothee Diogo(University of Helsinki), Emily Holzinger(University of Helsinki), Padhraig Gormley(University of Helsinki), Xulong Wang(University of Helsinki), Xing Chen(University of Helsinki), Åsa K. Hedman(Broad Institute), Kirsi Auro(University of Helsinki), Clarence Wang(Stanford University), Ethan Xu(University of Helsinki), Franck Augé(University of Helsinki), Clément Chatelain(University of Helsinki), Mitja Kurki(University of Helsinki), Samuli Ripatti(University of Helsinki), Mark J. Daly(Broad Institute), Juha Karjalainen(University of Helsinki), Aki S. Havulinna(University of Helsinki), Anu Jalanko(Finnish Red Cross), Kimmo Palin(Finnish Red Cross), Priit Palta(Finnish Red Cross), Pietro Della Briotta Parolo, Wei Zhou, Susanna Lemmelä(Borealis (Finland)), Manuel A. Rivas(Borealis (Finland)), Jarmo Harju(Borealis (Finland)), Aarno Palotie(Broad Institute), Arto Lehistö(Borealis (Finland)), Andrea Ganna(Tampere University), Vincent Llorens(University of Eastern Finland), Antti Karlsson(University of Eastern Finland), Kati Kristiansson(Central Finland Health Care District), Mikko Arvas(Central Finland Health Care District), Kati Hyvärinen(University of Turku), Jarmo Ritari(Finnish Institute for Health and Welfare), Tiina Wahlfors(Finnish Red Cross), Miika Koskinen, Olli Carpén(Borealis (Finland)), Johannes Kettunen(Tampere University), Katri Pylkäs(University of Eastern Finland), Marita Kalaoja(Central Finland Health Care District), Minna K. Karjalainen(University of Helsinki), Tuomo Mantere(University of Helsinki), Eeva Kangasniemi(University of Helsinki), Sami Heikkinen(University of Helsinki), Arto Mannermaa(University of Helsinki), Eija K. Laakkonen(University of Helsinki), Juha Kononen(University of Helsinki), Biobank directors(University of Helsinki), Lila Kallio(Broad Institute), Sirpa Soini(Broad Institute), Jukka Partanen(University of Helsinki), Kimmo Pitkänen(University of Helsinki), Seppo Vainio(University of Helsinki), Kimmo Savinainen(University of Helsinki), Veli‐Matti Kosma(University of Helsinki), Teijo Kuopio(University of Helsinki), FinnGen team(University of Helsinki), Administration(University of Helsinki), Anu Jalanko(University of Helsinki), Risto Kajanne(University of Helsinki), Ulrike Lyhs(University of Helsinki), Analysis(University of Helsinki), Mitja Kurki(University of Helsinki), Juha Karjalainen(University of Helsinki), Pietro della Briotta Parola, Sina Rüeger(Finnish Institute for Health and Welfare), Arto Lehistö(Finnish Institute for Health and Welfare), Wei Zhou(Finnish Institute for Health and Welfare), Masahiro Kanai(Finnish Institute for Health and Welfare), Hannele Laivuori(Finnish Institute for Health and Welfare), Aki S. Havulinna(University of Helsinki), Susanna Lemmelä(Finnish Institute for Health and Welfare), Tuomo Kiiskinen(University of Helsinki), Communication(Finnish Institute for Health and Welfare), Mari Kaunisto(Finnish Institute for Health and Welfare), Data management and IT infrastructure(University of Helsinki), Jarmo Harju(Finnish Institute for Health and Welfare), Elina Kilpeläinen(Finnish Institute for Health and Welfare), Timo P. Sipilä(University of Helsinki), Georg Brein(University of Helsinki), Oluwaseun Alexander Dada(University of Helsinki), Awaisa Ghazal(Pirkanmaa Hospital District), Anastasia Shcherban(Tampere University), Tuomas Sipilä(Tampere University), Genotyping(23andMe (United States)), Kati Donner(23andMe (United States)), Sample collection coordination(23andMe (United States)), Anu Loukola(23andMe (United States)), Sample logistics(23andMe (United States)), Päivi Laiho(23andMe (United States)), Tuuli Sistonen(23andMe (United States)), Essi Kaiharju(23andMe (United States)), Markku Laukkanen(23andMe (United States)), Elina Järvensivu(23andMe (United States)), Sini Lähteenmäki(23andMe (United States)), Lotta Männikkö(23andMe (United States)), Regis Wong(23andMe (United States)), Registry data operations(23andMe (United States)), Hannele Mattsson(23andMe (United States)), Kati Kristiansson(23andMe (United States)), Susanna Lemmelä(23andMe (United States)), Tero Hiekkalinna(23andMe (United States)), Manuel González Jiménez(23andMe (United States)), Sequencing informatics(23andMe (United States)), Priit Palta(23andMe (United States)), Kalle Pärn(23andMe (United States)), Javier Núñez-Fontarnau(23andMe (United States)), Trajectory team(23andMe (United States)), Tarja Laitinen(23andMe (United States)), Harri Siirtola(23andMe (United States)), Javier Gracia‐Tabuenca(Massachusetts Institute of Technology), Michelle Agee(University of Helsinki), Babak Alipanahi(Broad Institute), Adam Auton(University of Toronto), Robert K. Bell(Massachusetts General Hospital), Katarzyna Bryc(Brigham and Women's Hospital), Sarah L. Elson(University of Helsinki), Pierre Fontanillas(Tel Aviv University), Nicholas A. Furlotte(Verve Therapeutics (United States)), David A. Hinds(Harvard Stem Cell Institute), Karen E. Huber, Aaron Kleinman, Nadia K. Litterman, Jennifer C. McCreight, Matthew H. McIntyre, Joanna L. Mountain, Elizabeth S. Noblin, Carrie A. M. Northover, Steven J. Pitts, J. Fah Sathirapongsasuti, Olga V. Sazonova, Janie F. Shelton, Suyash Shringarpure, Chao Tian, Joyce Y. Tung, Vladimir Vacic, Catherine H. Wilson, Aviv Regev(Broad Institute), Aarno Palotie(Broad Institute), Benjamin M. Neale(Broad Institute), John E. Dick(University Health Network), Pradeep Natarajan(Broad Institute), Christopher J. O’Donnell, Mark J. Daly(Broad Institute), Michael Milyavsky(Tel Aviv University), Sekar Kathiresan(Broad Institute), Vijay G. Sankaran(Broad Institute)

Nature

October 14, 2020

10.1038/s41586-020-2786-7

Cited by 148Open Access

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