Integrative Biosynthetic Gene Cluster Mining to Optimize a Metabolic Pathway to Efficiently Produce <scp>l</scp>-Homophenylalanine in <i>Escherichia coli</i>
Zhen-Ning Liu(Tianjin University), Dengwei Lei(Tianjin University), Bin Qiao(Tianjin University), Shilin Li(Tianjin University), Jianjun Qiao(Tianjin University), Guang-Rong Zhao(Tianjin University)
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Abstract
produced 1.41 g/L of l-Hph from glucose in feeding shake-flask fermentation. Our cluster mining strategy enabled optimization of the target metabolic pathway, and it would be promising for production of other valuable products in the postgenomic era.
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