Decline of Humoral Responses against SARS-CoV-2 Spike in Convalescent Individuals
Guillaume Beaudoin-Bussières(Université de Montréal), Annemarie Laumaea(Université de Montréal), Sai Priya Anand(McGill University), Jérémie Prévost(Université de Montréal), Romain Gasser(Université de Montréal), Guillaume Goyette, Halima Medjahed, Josée Perreault(Héma-Québec), Tony Tremblay(Héma-Québec), Antoine Lewin(Héma-Québec), Laurie Gokool, Chantal Morrisseau, Philippe Bégin(Centre Hospitalier Universitaire Sainte-Justine), Cécile Tremblay(Université de Montréal), Valérie Martel‐Laferrière(Université de Montréal), Daniel E. Kaufmann(Université de Montréal), Jonathan Richard(Université de Montréal), Renée Bazin(Héma-Québec), Andrés Finzi(McGill University)
Cited by 215Open Access
Abstract
While waiting for an efficient vaccine to protect against SARS-CoV-2 infection, alternative approaches to treat or prevent acute COVID-19 are urgently needed. Transfusion of convalescent plasma to treat COVID-19 patients is currently being explored; neutralizing activity in convalescent plasma is thought to play a central role in the efficacy of this treatment. Here, we observed that plasma neutralization activity decreased a few weeks after the onset of the symptoms. If neutralizing activity is required for the efficacy of convalescent plasma transfer, our results suggest that convalescent plasma should be recovered rapidly after the donor recovers from active infection.
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