A high-stringency blueprint of the human proteome

Subash Adhikari(Macquarie University), Edouard C. Nice(Monash Health), Eric W. Deutsch(North Seattle College), Lydie Lane(SIB Swiss Institute of Bioinformatics), Gilbert S. Omenn(University of Michigan), Stephen R. Pennington(University College Dublin), Young‐Ki Paik(Yonsei University), Christopher M. Overall(University of British Columbia), Fernando J. Corrales(Centro Nacional de Biotecnología), Ileana M. Cristea(Princeton University), Jennifer E. Van Eyk(Cedars-Sinai Medical Center), Mathias Uhlén(KTH Royal Institute of Technology), Cecilia Lindskog(Uppsala University), Daniel W. Chan(Johns Hopkins University), Amos Bairoch(SIB Swiss Institute of Bioinformatics), J. Waddington(University College Dublin), Joshua Justice(Princeton University), Joshua LaBaer(Arizona State University), Henry Rodriguez(National Institutes of Health), Fuchu He(Beijing Proteome Research Center), Markus Kostrzewa(Knorr-Bremse (Germany)), Peipei Ping(University of California, Los Angeles), Rebekah L. Gundry(University of Nebraska Medical Center), Peter Stewart(Royal Prince Alfred Hospital), Sanjeeva Srivastava(Indian Institute of Technology Bombay), Sudhir Srivastava(National Institutes of Health), Fábio César Sousa Nogueira(Universidade Federal do Rio de Janeiro), Gilberto B. Domont(Universidade Federal do Rio de Janeiro), Yves Vandenbrouck(Inserm), Maggie P. Y. Lam(University of Colorado Anschutz Medical Campus), Sara A. Wennersten(University of Colorado Anschutz Medical Campus), Juan Antonio Vizcaíno(European Bioinformatics Institute), Marc R. Wilkins(UNSW Sydney), Jochen M. Schwenk(KTH Royal Institute of Technology), Emma Lundberg(KTH Royal Institute of Technology), Nuno Bandeira(University of California San Diego), György Marko‐Varga(Lund University), Susan T. Weintraub(The University of Texas at San Antonio Health Science Center), Charles Pineau(Inserm), Ulrike Kusebauch(North Seattle College), Robert L. Moritz(North Seattle College), Seong Beom Ahn(Macquarie University), Magnus Palmblad(Leiden University Medical Center), M Snyder(Stanford Medicine), Ruedi Aebersold(North Seattle College), Mark S. Baker(Stanford Medicine)
Nature Communications
October 16, 2020
10.1038/s41467-020-19045-9
Cited by 217Open Access
Full Text

Abstract

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

Related Papers

No related papers found

Powered by citation graph analysis