A Prospective Study of Neurologic Disorders in Hospitalized Patients With COVID-19 in New York City

Jennifer Frontera(Johns Hopkins University), Sakinah Sabadia(Johns Hopkins University), Rebecca Lalchan(Johns Hopkins University), Taolin Fang(Johns Hopkins University), Brent Flusty(Johns Hopkins University), Patricio Millar Vernetti(Johns Hopkins University), Thomas E. Snyder(Johns Hopkins University), S Berger(Johns Hopkins University), Dixon Yang(Johns Hopkins University), Andre Granger(Johns Hopkins University), Nicole Morgan(Johns Hopkins University), Palak Patel(Johns Hopkins University), Josef Gutman(Johns Hopkins University), Kara Melmed(Johns Hopkins University), Shashank Agarwal(Johns Hopkins University), Matthew Bokhari(Johns Hopkins University), Andres Andino(Johns Hopkins University), Eduard Valdes(Johns Hopkins University), Mirza Omari(Johns Hopkins University), Alexandra Kvernland(Johns Hopkins University), Kaitlyn Lillemoe(Johns Hopkins University), Sherry Chou(Johns Hopkins University), Molly McNett(Johns Hopkins University), Raimund Helbok(Johns Hopkins University), Shraddha Mainali(Johns Hopkins University), Ericka L. Fink(Johns Hopkins University), Courtney Robertson(Johns Hopkins University), Michelle E. Schober(Johns Hopkins University), José I. Suarez(Johns Hopkins University), Wendy Ziai(Johns Hopkins University), David Menon(Johns Hopkins University), Daniel Friedman(Johns Hopkins University), David Friedman(Johns Hopkins University), Manisha Holmes(Johns Hopkins University), Joshua Zhexue Huang(Johns Hopkins University), Sujata Thawani(Johns Hopkins University), Jonathan Howard(Johns Hopkins University), Nada Abou-Fayssal(Johns Hopkins University), Penina Krieger(Johns Hopkins University), Ariane Lewis(Johns Hopkins University), Aaron Lord(Johns Hopkins University), Ting Zhou(Johns Hopkins University), D. Ethan Kahn(Johns Hopkins University), Barry Czeisler(Johns Hopkins University), Jose Torres(Johns Hopkins University), Shadi Yaghi(Johns Hopkins University), Koto Ishida(Johns Hopkins University), Erica Scher(Johns Hopkins University), Adam de Havenon(Johns Hopkins University), Dimitris G. Placantonakis(Johns Hopkins University), Mengling Liu(Johns Hopkins University), Thomas Wısnıewskı(Johns Hopkins University), Andrea B. Troxel(Johns Hopkins University), Laura J. Balcer(Johns Hopkins University), Steven Galetta(Johns Hopkins University)
Neurology
October 6, 2020
10.1212/wnl.0000000000010979
Cited by 305Open Access
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Abstract

OBJECTIVE: To determine the prevalence and associated mortality of well-defined neurologic diagnoses among patients with coronavirus disease 2019 (COVID-19), we prospectively followed hospitalized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients and recorded new neurologic disorders and hospital outcomes. METHODS: We conducted a prospective, multicenter, observational study of consecutive hospitalized adults in the New York City metropolitan area with laboratory-confirmed SARS-CoV-2 infection. The prevalence of new neurologic disorders (as diagnosed by a neurologist) was recorded and in-hospital mortality and discharge disposition were compared between patients with COVID-19 with and without neurologic disorders. RESULTS: < 0.001). CONCLUSIONS: Neurologic disorders were detected in 13.5% of patients with COVID-19 and were associated with increased risk of in-hospital mortality and decreased likelihood of discharge home. Many observed neurologic disorders may be sequelae of severe systemic illness.

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