Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

Marie Wong; Chelsea Mayoh; Loretta M. S. Lau; Dong-Anh Khuong-Quang; Mark Pinese; Amit Kumar; Paulette Barahona; Emilie Wilkie; Patricia A. Sullivan; Rachel Bowen-James; Mustafa Syed; Iñigo Martincorena; Federico Abascal; Alexandra Sherstyuk; Noemi Fuentes-Bolanos; Jonathan Baber; Peter Priestley; M. Emmy M. Dolman; Emmy D.G. Fleuren; Marie-Emilie Gauthier; Emily Mould; Velimir Gayevskiy; Andrew J. Gifford; Dylan Grebert‐Wade; Patrick Strong; Elodie Manouvrier; Meera Warby; David M. Thomas; Judy Kirk; Kathy Tucker; Tracey O’Brien; Frank Alvaro; Geoffrey McCowage; Luciano Dalla‐Pozza; Nicholas G. Gottardo; Heather Tapp; Paul Wood; Seong Lin Khaw; Jordan R. Hansford; Andrew S. Moore; Murray D. Norris; Toby N. Trahair; Richard B. Lock; Vanessa Tyrrell; Michelle Haber; Glenn M. Marshall; David S. Ziegler; Paul G. Ekert; Mark J. Cowley

doi:10.1038/s41591-020-1072-4

Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

Marie Wong(Garvan Institute of Medical Research), Chelsea Mayoh(UNSW Sydney), Loretta M. S. Lau(UNSW Sydney), Dong-Anh Khuong-Quang(Royal Children's Hospital), Mark Pinese(Garvan Institute of Medical Research), Amit Kumar(Peter MacCallum Cancer Centre), Paulette Barahona(UNSW Sydney), Emilie Wilkie(UNSW Sydney), Patricia A. Sullivan(UNSW Sydney), Rachel Bowen-James(UNSW Sydney), Mustafa Syed(UNSW Sydney), Iñigo Martincorena(Wellcome Sanger Institute), Federico Abascal(Wellcome Sanger Institute), Alexandra Sherstyuk(UNSW Sydney), Noemi Fuentes-Bolanos(UNSW Sydney), Jonathan Baber(Hartwig Medical Foundation), Peter Priestley(Hartwig Medical Foundation), M. Emmy M. Dolman(UNSW Sydney), Emmy D.G. Fleuren(UNSW Sydney), Marie-Emilie Gauthier(UNSW Sydney), Emily Mould(UNSW Sydney), Velimir Gayevskiy(Garvan Institute of Medical Research), Andrew J. Gifford(UNSW Sydney), Dylan Grebert‐Wade(UNSW Sydney), Patrick Strong(UNSW Sydney), Elodie Manouvrier(UNSW Sydney), Meera Warby(Children's Hospital at Westmead), David M. Thomas(Garvan Institute of Medical Research), Judy Kirk(Westmead Hospital), Kathy Tucker(Prince of Wales Hospital), Tracey O’Brien(UNSW Sydney), Frank Alvaro(John Hunter Children's Hospital), Geoffrey McCowage(Children's Hospital at Westmead), Luciano Dalla‐Pozza(Children's Hospital at Westmead), Nicholas G. Gottardo(The Kids Research Institute Australia), Heather Tapp(Women's and Children's Hospital), Paul Wood(Monash Children’s Hospital), Seong Lin Khaw(Royal Children's Hospital), Jordan R. Hansford(Royal Children's Hospital), Andrew S. Moore(The University of Queensland), Murray D. Norris(UNSW Sydney), Toby N. Trahair(UNSW Sydney), Richard B. Lock(UNSW Sydney), Vanessa Tyrrell(UNSW Sydney), Michelle Haber(UNSW Sydney), Glenn M. Marshall(UNSW Sydney), David S. Ziegler(Cancer Institute of New South Wales), Paul G. Ekert(Royal Children's Hospital), Mark J. Cowley(Garvan Institute of Medical Research)

Nature Medicine

October 5, 2020

10.1038/s41591-020-1072-4

Cited by 402Open Access

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