The role of microenvironment in tumor angiogenesis

Xianjie Jiang(Central South University), Jie Wang(Central South University), Xiangying Deng(Central South University), Fang Xiong(Central South University), Shanshan Zhang(Central South University), Zhaojian Gong(Central South University), Xiayu Li(Central South University), Ke Cao(Central South University), Hao Deng(Central South University), Yi He(Central South University), Qianjin Liao(Central South University), Bo Xiang(Central South University), Ming Zhou(Central South University), Can Guo(Central South University), Zhaoyang Zeng(Central South University), Guiyuan Li(Central South University), Xiaoling Li(Central South University), Wei Xiong(Central South University)
Journal of Experimental & Clinical Cancer Research
September 30, 2020
10.1186/s13046-020-01709-5
Cited by 750Open Access
Full Text

Abstract

Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment-composed of tumor cells, surrounding cells, and secreted cytokines-provides a conducive environment for the growth and survival of tumors. Different components of the tumor microenvironment can regulate tumor development. In this review, we have discussed the regulatory role of the microenvironment in tumor angiogenesis. High expression of angiogenic factors and inflammatory cytokines in the tumor microenvironment, as well as hypoxia, are presumed to be the reasons for poor therapeutic efficacy of current anti-angiogenic drugs. A combination of anti-angiogenic drugs and antitumor inflammatory drugs or hypoxia inhibitors might improve the therapeutic outcome.

Related Papers

No related papers found

Powered by citation graph analysis