MAIT cell activation and dynamics associated with COVID-19 disease severity
Tiphaine Parrot(Karolinska University Hospital), Jean‐Baptiste Gorin(Karolinska University Hospital), Andrea Ponzetta(Karolinska University Hospital), Kimia T. Maleki(Karolinska University Hospital), Tobias Kammann(Karolinska University Hospital), Johanna Emgård(Karolinska University Hospital), André Perez‐Potti(Karolinska University Hospital), Takuya Sekine(Karolinska University Hospital), Olga Rivera‐Ballesteros(Karolinska University Hospital), the Karolinska COVID-19 Study Group(Karolinska University Hospital), Sara Gredmark‐Russ(Karolinska University Hospital), Olav Rooyackers(Karolinska University Hospital), Elin Folkesson(Karolinska University Hospital), Lars I. Eriksson(Karolinska University Hospital), Anna Norrby‐Teglund(Karolinska University Hospital), Hans-Gustaf Ljunggren(Karolinska University Hospital), Niklas K. Björkström(Karolinska University Hospital), Soo Aleman(Karolinska University Hospital), Marcus Buggert(Karolinska University Hospital), Jonas Klingström(Karolinska University Hospital), Kristoffer Strålin(Karolinska University Hospital), Johan K. Sandberg(Karolinska University Hospital), John Tyler Sandberg(Karolinska University Hospital), Helena Bergsten(Karolinska University Hospital), Niklas K. Björkström(Karolinska University Hospital), Susanna Brighenti(Karolinska University Hospital), Marcus Buggert(Karolinska University Hospital), Marta Butrym, Benedict J. Chambers, Puran Chen, Martin Cornillet, Angélica Cuapio, Isabel Diaz Lozano, Majda Dzidic(Karolinska University Hospital), Johanna Emgård(Karolinska University Hospital), Malin Flodström‐Tullberg(Karolinska University Hospital), Jean‐Baptiste Gorin(Karolinska University Hospital), Sara Gredmark‐Russ(Karolinska University Hospital), Alvaro Haroun-Izquierdo, Laura Hertwig, Sadaf Kalsum(Karolinska University Hospital), Jonas Klingström(Karolinska University Hospital), Efthymia Kokkinou, Egle Kvedaraite(Karolinska University Hospital), Hans-Gustaf Ljunggren(Karolinska University Hospital), Magda Lourda(Karolinska University Hospital), Kimia T. Maleki(Karolinska University Hospital), Karl‐Johan Malmberg, Jakob Michaëlsson, Jenny Mjösberg, Kirsten Moll, Jagadeeswara Rao Muvva(Karolinska University Hospital), Anna Norrby‐Teglund(Karolinska University Hospital), Laura M. Palma Medina(Karolinska University Hospital), Tiphaine Parrot(Karolinska University Hospital), Lena Radler, Emma Ringqvist(Karolinska University Hospital), Johan K. Sandberg(Karolinska University Hospital), Takuya Sekine(Karolinska University Hospital), Tea Soini, Mattias Svensson, Janne Tynell, Andreas von Kries, David Wullimann(Karolinska University Hospital), André Perez‐Potti(Karolinska University Hospital), Olga Rivera‐Ballesteros(Karolinska University Hospital), Christopher Maucourant, Renata Varnaitė, Mira Akber, Lena Berglin, Demi Brownlie, Marco Giulio Loreti, Ebba Sohlberg(Karolinska University Hospital), Tobias Kammann(Karolinska University Hospital), Elisabet Welin Henriksson, Nicole Marquardt(Karolinska University Hospital), Kristoffer Strålin(Karolinska University Hospital), Soo Aleman(Karolinska University Hospital), Anders Sönnerborg, Lena Dillner(Karolinska University Hospital), Anna Färnert, Hedvig Glans, Pontus Nauclér(Karolinska University Hospital), Olav Rooyackers(Karolinska University Hospital), Johan Mårtensson(Karolinska University Hospital), Lars I. Eriksson(Karolinska University Hospital), Björn P. Persson, Jonathan Grip, Christian Unge
Cited by 210Open Access
Abstract
immunotypes associated with poor clinical outcome. MAIT cell levels normalized in the convalescent phase, consistent with dynamic recruitment to the tissues and later release back into the circulation when disease is resolved. These findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis.
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