FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma
Ying Wang(Sun Yat-sen University Cancer Center), Zhaojie Lyu(University of Hong Kong), Yanru Qin(First Affiliated Hospital of Zhengzhou University), Xia Wang(University of Hong Kong), Liang-Zhan Sun(University of Hong Kong), Yu Zhang(University of Hong Kong), Lanqi Gong(University of Hong Kong), Shayi Wu(University of Hong Kong), Shuo Han(University of Hong Kong), Ying Tang(University of Hong Kong), Yongxu Jia(First Affiliated Hospital of Zhengzhou University), Dora Lai‐Wan Kwong(University of Hong Kong), Ngar‐Woon Kam(University of Hong Kong), Xin‐Yuan Guan(First Affiliated Hospital of Zhengzhou University)
Cited by 168Open Access
Abstract
FOXO1 facilitated M0-to-M2 polarization and the recruitment of M2 macrophages in the TME via the transcriptional modulation of CCL20 and CSF-1. Our data deciphered the FOXO1-dependent mechanism in M2 macrophage infiltration in the TME of ESCC, which has implications for the development of novel prognostic and therapeutic targets to optimize the current treatment against ESCC.
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