Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients
Carl A. Pierce(Albert Einstein College of Medicine), Paula Preston‐Hurlburt(Yale University), Yile Dai(Yale University), Clare Burn Aschner(Albert Einstein College of Medicine), Natalia Cheshenko(Children's Hospital at Montefiore), Benjamin Galen(Montefiore Medical Center), S. Garforth(Albert Einstein College of Medicine), Natalia G. Herrera(Albert Einstein College of Medicine), Rohit K. Jangra(Albert Einstein College of Medicine), Nicholas C. Morano(Albert Einstein College of Medicine), Erika P. Orner(Montefiore Medical Center), Sharlene Sy(Children's Hospital at Montefiore), Kartik Chandran(Albert Einstein College of Medicine), James Dziura(Yale University), Steven C. Almo(Albert Einstein College of Medicine), Aaron M. Ring(Yale University), Marla J. Keller(Montefiore Medical Center), Kevan C. Herold(Yale University), Betsy C. Herold(Albert Einstein College of Medicine)
Cited by 391Open Access
Abstract
T cells. Moreover, serum neutralizing antibody titers and antibody-dependent cellular phagocytosis were higher in adults compared to pediatric patients with COVID-19. The neutralizing antibody titer correlated positively with age and negatively with IL-17A and IFN-γ serum concentrations. There were no differences in anti-spike protein antibody titers to other human coronaviruses. Together, these findings demonstrate that the poor outcome in hospitalized adults with COVID-19 compared to children may not be attributable to a failure to generate adaptive immune responses.
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