Bioorthogonal Reactions in Animals
Karine Porte(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Maxime Ribéraud(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Rémi Châtre(Centre National de la Recherche Scientifique), Davide Audisio(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Sébastien Papot(Centre National de la Recherche Scientifique), Frédéric Taran(Commissariat à l'Énergie Atomique et aux Énergies Alternatives)
Cited by 39
Abstract
The advent of bioorthogonal chemistry has led to the development of powerful chemical tools that enable increasingly ambitious applications. In particular, these tools have made it possible to achieve what is considered to be the holy grail of many researchers involved in chemical biology: to perform unnatural chemical reactions within living organisms. In this minireview, we present an update of bioorthogonal reactions that have been carried out in animals for various applications. We outline the advances made in the understanding of fundamental biological processes, and the development of innovative imaging and therapeutic strategies using bioorthogonal chemistry.
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