Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19
Elizabeth R. Mann(Manchester Academic Health Science Centre), Madhvi Menon(Manchester Academic Health Science Centre), Sean Knight(Manchester Academic Health Science Centre), Joanne E. Konkel(Manchester Academic Health Science Centre), Christopher Jagger(Manchester Academic Health Science Centre), Tovah N. Shaw(Manchester Academic Health Science Centre), Siddharth Krishnan(Manchester Academic Health Science Centre), Magnus Rattray(University of Manchester), Andrew Ustianowski(North Manchester General Hospital), Nawar Diar Bakerly(Salford Royal NHS Foundation Trust), Paul Dark(Salford Royal NHS Foundation Trust), Graham M. Lord(Manchester Academic Health Science Centre), Angela Simpson(Wythenshawe Hospital), Timothy Felton(Wythenshawe Hospital), Ling‐Pei Ho(University of Oxford), NIHR Respiratory TRC(Nuffield Orthopaedic Centre), Marc Feldmann(Manchester Academic Health Science Centre), CIRCO(Manchester Academic Health Science Centre), John R. Grainger(Manchester Academic Health Science Centre), Tracy Hussell(Manchester Academic Health Science Centre)
Cited by 257Open Access
Abstract
-67. Longitudinal analysis revealed reversion of some immune features back to the healthy median level in patients with a good eventual outcome. These findings identify previously unappreciated alterations in the innate immune compartment of COVID-19 patients and lend support to the idea that therapeutic strategies targeting release of myeloid cells from bone marrow should be considered in this disease. Moreover, they demonstrate that features of an exaggerated immune response are present early after hospital admission suggesting immune-modulating therapies would be most beneficial at early timepoints.
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