Determinants of telomere length across human tissues
Kathryn Demanelis(Chicago Department of Public Health), Farzana Jasmine(Chicago Department of Public Health), Lin Chen(Chicago Department of Public Health), Meytal Chernoff(Chicago Department of Public Health), Tong Lin(Chicago Department of Public Health), Dayana Delgado(Chicago Department of Public Health), Chenan Zhang(Chicago Department of Public Health), Justin Shinkle(Chicago Department of Public Health), Mekala Sabarinathan(Chicago Department of Public Health), Hannah Lin(Chicago Department of Public Health), Eduardo Ramirez(Chicago Department of Public Health), Meritxell Oliva(Chicago Department of Public Health), Sarah Kim-Hellmuth(Max Planck Institute of Psychiatry), Barbara E. Stranger(Northwestern University), Tsung‐Po Lai(Rutgers, The State University of New Jersey), Abraham Aviv(Rutgers, The State University of New Jersey), Kristin Ardlie(Broad Institute), François Aguet(Broad Institute), Habibul Ahsan(Chicago Department of Public Health), Jennifer A. Doherty(University of Utah), Muhammad G. Kibriya(Chicago Department of Public Health), Brandon L. Pierce(Chicago Department of Public Health), François Aguet(Broad Institute), Shankara Anand, Kristin Ardlie(Broad Institute), Stacey Gabriel, Gad Getz, Aaron Graubert, Kane Hadley, Robert E. Handsaker, Katherine Huang, Seva Kashin, Xiao Li, Daniel G. MacArthur, Samuel R. Meier, Jared L. Nedzel, Duyen T. Nguyen, Ayellet V. Segrè, Ellen Todres, Brunilda Balliu, Alvaro Barbeira, Alexis Battle, Rodrigo Bonazzola, Andrew Brown, Christopher Brown, Stephane E. Castel, Donald F. Conrad, Daniel J. Cotter, Nancy J. Cox, Sayantan Das, Olivia M. de Goede, Emmanouil T. Dermitzakis, Jonah Einson, Barbara E. Engelhardt, Eleazar Eskin, Tiffany Eulalio, Nicole M. Ferraro, Elise D. Flynn, Laure Frésard, Eric R. Gamazon, Diego Garrido-Martín, Nicole R. Gay, Michael J. Gloudemans, Roderic Guigó, Andrew R. Hame, Yuan He, Paul Hoffman, Farhad Hormozdiari, Lei Hou, Hae Kyung Im, Brian Jo, Silva Kasela, Manolis Kellis, Sarah Kim-Hellmuth(Max Planck Institute of Psychiatry), Alan Kwong, Tuuli Lappalainen, Xin Li, Yanyu Liang, Serghei Mangul, Pejman Mohammadi, Stephen B. Montgomery, Manuel Muñoz-Aguirre, Daniel Nachun, Andrew B. Nobel, Meritxell Oliva(Chicago Department of Public Health), YoSon Park, Yongjin Park, Princy Parsana, Abhiram Rao, Ferrán Reverter, John M. Rouhana, Chiara Sabatti, Ashis Saha, Matthew Stephens, Barbara E. Stranger(Northwestern University), Benjamin J. Strober, Nicole A. Teran, Ana Viñuela, Gao Wang, Xiaoquan Wen, Fred A. Wright, Valentin Wucher, Yuxin Zou, Pedro G. Ferreira, Gen Li, Marta Melé, Esti Yeger‐Lotem, Mary E. Barcus, Debra Bradbury, Tanya Krubit, Jeffrey A. McLean, Liqun Qi, Karna Robinson, Nancy Roche, Anna Marie Smith, Leslie H. Sobin, David E. Tabor, Anita H. Undale, Jason Bridge, Lori E. Brigham, Barbara A. Foster, Bryan M. Gillard, Richard Hasz, Marcus Anthony Hunter, Christopher Johns, Mark P. Johnson, Ellen Karasik, Gene Kopen, William F. Leinweber, Alisa McDonald, Michael T. Moser, Kevin Myer, Kimberley D. Ramsey, Brian Roe, Saboor Shad, Jeffrey A. Thomas, Gary Walters, Michael Washington, J. Gary Wheeler, Scott D. Jewell, Daniel C. Rohrer, Dana R. Valley, David A. Davis, Deborah C. Mash, Philip A. Branton, Laura K. Barker, Heather M. Gardiner, Maghboeba Mosavel, Laura A. Siminoff, Paul Flicek, Maximilian Haeussler, Thomas Juettemann, Wm. Kent, Christopher M. Lee, Conner C. Powell, Kate R. Rosenbloom, Magali Ruffier, Dan Sheppard, Kieron Taylor, Stephen J. Trevanion, Daniel R. Zerbino, Nathan S. Abell, Joshua M. Akey, Lin Chen(Chicago Department of Public Health), Kathryn Demanelis(Chicago Department of Public Health), Jennifer A. Doherty(University of Utah), Andrew P. Feinberg, Kasper D. Hansen, Peter F. Hickey, Farzana Jasmine(Chicago Department of Public Health), Lihua Jiang, Rajinder Kaul, Muhammad G. Kibriya(Chicago Department of Public Health), Jin Billy Li, Li Qin, Shin Lin, Sandra E. Linder, Brandon L. Pierce(Chicago Department of Public Health), Lindsay F. Rizzardi, Andrew D. Skol, Kevin S. Smith, M Snyder, J Stamatoyannopoulos, Hua Tang, Meng C. Wang, Latarsha J. Carithers, Ping Guan, Susan E. Koester, A. Roger Little, Helen M. Moore, Concepcion R. Nierras, Abhi K. Rao, Jimmie B. Vaught, Simona Volpi
Cited by 492Open Access
Abstract
Telomere shortening is a hallmark of aging. Telomere length (TL) in blood cells has been studied extensively as a biomarker of human aging and disease; however, little is known regarding variability in TL in nonblood, disease-relevant tissue types. Here, we characterize variability in TLs from 6391 tissue samples, representing >20 tissue types and 952 individuals from the Genotype-Tissue Expression (GTEx) project. We describe differences across tissue types, positive correlation among tissue types, and associations with age and ancestry. We show that genetic variation affects TL in multiple tissue types and that TL may mediate the effect of age on gene expression. Our results provide the foundational knowledge regarding TL in healthy tissues that is needed to interpret epidemiological studies of TL and human health.
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