Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity
Carolyn Rydyznski Moderbacher(La Jolla Institute for Immunology), Sydney I. Ramirez(La Jolla Institute for Immunology), Jennifer M. Dan(La Jolla Institute for Immunology), Alba Grifoni(La Jolla Institute for Immunology), Kathryn M. Hastie(La Jolla Institute for Immunology), Daniela Weiskopf(La Jolla Institute for Immunology), Simon Bélanger(La Jolla Institute for Immunology), Robert Abbott(La Jolla Institute for Immunology), Christina Kim(La Jolla Institute for Immunology), Jinyong Choi(La Jolla Institute for Immunology), Yu Kato(La Jolla Institute for Immunology), Eleanor G. Crotty(La Jolla Institute for Immunology), Cheryl Kim(La Jolla Institute for Immunology), Stephen A. Rawlings(University of California San Diego), José Mateus(La Jolla Institute for Immunology), Longping V. Tse(University of North Carolina at Chapel Hill), April Frazier(La Jolla Institute for Immunology), Ralph S. Baric(University of North Carolina at Chapel Hill), Bjoern Peters(La Jolla Institute for Immunology), Jason Greenbaum(La Jolla Institute for Immunology), Erica Ollmann Saphire(La Jolla Institute for Immunology), Davey M. Smith(University of California San Diego), Alessandro Sette(La Jolla Institute for Immunology), Shane Crotty(La Jolla Institute for Immunology)
Cited by 1,971Open Access
Abstract
T cell, and antibody responses are protective, but uncoordinated responses frequently fail to control disease, with a connection between aging and impaired adaptive immune responses to SARS-CoV-2.
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