Effect of Dapagliflozin in DAPA-HF According to Background Glucose-Lowering Therapy
Kieran F. Docherty(University of Glasgow), Pardeep S. Jhund(University of Glasgow), Olof Bengtsson(AstraZeneca (Sweden)), David L. DeMets(University of Wisconsin–Madison), Silvio E. Inzucchi(Yale University), Lars Køber(Copenhagen University Hospital), Mikhail Kosiborod(UNSW Sydney), Anna Maria Langkilde(AstraZeneca (Sweden)), Felipe A. Martínez(Universidad Nacional de Córdoba), Marc S. Sabatine(Brigham and Women's Hospital), Mikaela Sjöstrand(AstraZeneca (Sweden)), Scott D. Solomon(Brigham and Women's Hospital), John J.V. McMurray(University of Glasgow), Mirta Díez, Sonia A Sassone, Diego Aizenberg, María L. Talavera(AstraZeneca (Sweden)), Guillermo Mercau, Diego Martinez(Universidad Nacional de Córdoba), Juan Pablo Albisu, Alejandro Hershson, Rubén GarcíaDurán, Miguel Hominal, Natalia Cluigt, Fernando ColomboBerra, Eduardo Perna, Rodolfo AhuadGuerrero, Daniela GarcíaBrasca, Cesar Javier Zaidman, Claudio Majul, José Taborda, Hugo A Luquez, Jorgelina Sala, Alvaro SosaLiprandi, Guillermo Cursack, Oscar Montaña, AlbertoAlfredo Fernandez, Martín Najenson(Universidad Nacional de Córdoba), S Nani, G Caruso, Enrique Fairman, Stella PereiroGonzalez, Lília Nigro Maia, Adamastor Humberto Pereira, Paulo Roberto Ferreira ROSSI, Dalton Bertolim Précoma, Fernando Carvalho Neuenschwander, Gilmar Reis, Fabio Augusto Bronzi Guimarães, José Francisco Kerr Saraiva, Flavia Arantes, Mauro Esteves Hernandes, João Carlos de Oliveira Borges, Bruno Paolino, Eduardo Vasconcellos, Euler Roberto Fernandes Manenti, Pedro Pimentel, Paulo Leães, Salvador Rassi, Talia Falcão Dalçóquio, Tsvetana Katova, D Avramov, Nataliya Spasova, Dimitar Raev, Boryana Chompalova, Maria Milanova(AstraZeneca (Sweden)), Maria Tokmakova(AstraZeneca (Sweden)), N. Runev, Atanas Mihov, Antoni Gogov, Adriana Dincheva, Nikolay Iliev, Borislav Kolomanov, Yuliyana Ivanova, Katya Ilieva, Dimitar Karageorgiev, Ivan Petrov, Nikolay Botushanov, S Vladeva, Christian Constance, Saul Vizel, A. Shekhar Pandey, Denis-Carl Phaneuf, Shamir R. Mehta, Dennis Rupka, Yves Pesant, Paul Poirier, R Chehayeb, Mohan Babapulle, Eileen O’Meara, Jonathan G. Howlett, Louis Yao, Robert S. McKelvie, Subodh Verma, Michael Hartleib, Ram Vijayaraghavan, John Vyselaar(University of Glasgow), Fabián Azzari, James Cha, Farah Nasser-Sharif, TunZan Maung, Samer Mansour, Yaariv Khaykin, Rina Lee, Peter C.C. Fong, Junbo Ge, Hong Jiang, Xinli Li(Universidad Nacional de Córdoba), Lu Fu, Ying Li(Universidad Nacional de Córdoba), Dongfang Wang, Qiang Zhao, Yugang Dong, Yimeng Zhou, Xiu-Fang Lin, Jianzeng Dong, Xiaoli Zhang, Zeqi Zheng, Wenjun Huang, Ye Gu, Jinqiu Liu, X Guo, Ling Wu, Qizhu Tang, Daoquan Peng, Wei Dong, Yingzi Liang, Daying Wang, Chun‐Ying Wu, Zhanquan Li(Universidad Nacional de Córdoba), Xuefeng Lin, Xuelian Zhang, Zhirong Wang, Bing Han, Jan Bělohlávek, Josef Slaby, Jindřich Špinar, Petr Hájek, Ladislav Busak, Jiri Carda, Lenka Špinarová, Ivan Málek, Jiří Škopek, Roman Kuchar, Eva Krčová, Otto Mayer, Dusan Kucera, Morten Schou, Lars Køber(Copenhagen University Hospital), Kenneth Egstrup, JensDahlgaard Hove, Gunnar Gislason, Lars Videbæk(Copenhagen University Hospital), Michael Böhm, Ruth Nischik, Nicole Toursarkissian, Karl‐Friedrich Appel, Ekkehard Schmidt, Ingo Weigmann, Monika Kellerer, Ayham Al-Zoebi, Uta Stephan, Andreas Wilke, Sabine Genth‐Zotz, Gregor Simonis, Diethelm Tschöpe, Angelika Costard‐Jäckle, Mark C. Petrie, Roy S. Gardner, Andrew L. Clark, Alan G. Japp(AstraZeneca (Sweden)), Pardeep S. Jhund(University of Glasgow), Chim C. Lang(AstraZeneca (Sweden)), Stephen J Leslie, Clare Murphy, Colin J. Petrie, John Walsh(University of Glasgow), Béla Merkely, Péter Andrássy, Ebrahim Noori, Zoltán Járai, F Poór, Csaba Király(Brigham and Women's Hospital), Anna Czigány(AstraZeneca (Sweden)), László Nagy, Ákos Motyovszki, Gabriella Masszi, Vimal Mehta, Vijay Chopra(University of Glasgow), Ajay Naik, Milind Gadkari, Rahul Sawant, Mashhadi Mahapekar, Sunil Karna, Mukund Deshpande, Varun Bhargava, V A Kothiwale, Jaideep Menon, Dhurjati Prasad Sinha, Santosh Kumar Sinha, Hemant Kokane, Prashant Udgire, Manjinder S. Sandhu, Masahiro Suzuki, Masami Nishino, Arihiro Kiyosue, Kotaro Sumii, Shu Suzuki, Yuichi Noguchi, Shinji Tanaka, Horoyuki Takase, Masahiro Mohri, Shinichi Higashiue, Noritaka Fujimoto, Harukazu Iseki, Takehiko Kuramochi, Taro Shibasaki, Hiroshi Tsutsui, Yuichiro Takagi, Satoru Sakuragi, Noriyuki Takeyasu, Masahumi Kitakaze, Chisato Izumi, Takafumi Oga, Akira Kimura, Tsunekazu Kakuta, Tetsuo Hashimoto, Hiroshi Sugino, Kozue Saito, Shitoshi Hiroi, Haruo Kamiya, Kazuki Fukui, Satoshi Matsuoka, Kazunori Moritani, Yoshiaki Tomobuchi, Yoshiki Hata, Ryo Kawamura, Eijiro Hattori, Kazuteru Fujimoto, Natsuki Takahashi, Wataru Takahashi, Toshiaki Kadokami, Hideki Ueno, Shinichiro Uchikawa, Tsuyoshi Shinozaki, Yuko Onishi, Nobuyuki Komiyama, Shujiro Inoue, Yukihiko Momiyama, Yasunori Ueda, Yasuo Komura, Ryo Hayashida, Seigo Masuda, Motoaki Higuchi, Yasushi Hayashi, Kozaburo Seki, Kenshi Fujii, Ken Harada, Atsuyuki Wada, Takatoshi Kasai, Koichiro Kuwahara, Shogo Oishi, Issei Uchida, Yasuo Okumura, Yuji Hisamatsu, Tatsuya Nunohiro, Kengo Tsukahara, Atsushi Hirohata, Masanori Asakura, Rudolf deBoer, Louise Bellersen, Henk P. Swart, Björn E. Groenemeijer, S K Zoet-Nugteren, Cornelis deNooijer, Pieter M. H. Nierop, Ramon RoblesdeMedina, Jacob vanEck, Maarten vanHessen, Jarosław Dróżdż, Paweł Miękus, R Ściborski, Beata Mikłaszewicz, Wanda Sudnik, Rafał Mariankowski, Robert Witek, Grzegorz Drelich, Ewa Mirek-Bryniarska, Sławomir Szynal, Lidia Pawłowicz, Jacek Lampart, Romuald Korzeniak, Janusz Prokopczuk, С. А. Болдуева, Yury Didenko, Nino Dzhaiani, Lyudmila Ermoshkina, Victor Kostenko, Еlena A. Vishneva, Natalia Koziolova, Sergey Tereschenko, Dmitrii Pevzner, Людмила Геннадьевна Крылова, A. M. Chernyavsky, Andrei Kazakov, Sergei Aksentiev, Rostislav Nilk, Zhanna Paltsman, А. S. Galyavich, Alexey Maltcev, Philipp Kopylov, Andrey Ezhov, Julia V. Shilko, Lubomir Antalik, Viliam Bugan, Peter Fulop, Livia Jamriskova, Daniela Kollarova, Vladimir Macek, Maria Slovenska(AstraZeneca (Sweden)), Livia Tomasova, Daniela Vinanska, Rudolf Smik, Juraj Selecky, Ivan Majerčák, Peter Olexa, Charlotta Ljungman, Anders Hedman, Carl-Johan Lindholm, Krister Lindmark, Thomas Mooe, Chern En Chiang, Lian‐Yu Lin, Mingen Liu, Kuan‐Cheng Chang, Chien‐Hsun Hsia, Jhih‐Yuan Shih, Ping‐Yen Liu, Tsung‐Hsien Lin, Hung‐Yu Chang, Jin‐Long Huang, Ching‐Lin Hsieh, Chih‐Cheng Wu, Wei‐Kung Tseng, Ahmed Arif, David Avino(University of Wisconsin–Madison), Supratim Banerjee, Manreet Kanwar, Martin Berk(Universidad Nacional de Córdoba), Christopher Brown, Carlos Ince, Todd Lewis, Akbar Nikfarjam, Jignesh M. Patel, Kodangudi B. Ramanathan, Alexander Schabauer, Trevor Greene, Keyur B. Shah, Rodolfo Sotolongo, Amado Viera, Olakunle O. Akinboboye, Amy Arouni, Barry Bertolet, Lokesh Chandra, Thomas R. Cimato, Samuel DeLeon, Mosi K. Bennett, Francesco Franchi, Glenn S. Hamroff, David R. Hotchkiss(University of Wisconsin–Madison), Michael Jardula, Julian Javier, Navid Kazemi, John B. Kostis(University of Glasgow), Joseph A. Lash, Lawrence S. Levinson, Ira Lieber, Eric Lo(Brigham and Women's Hospital), Sharan Mahal, Ramin Manshadi, Freny Vaghaiwalla Mody, Alexander Paraschos, Michael Pursley, Gavin Hickey, Juan Luis Londoño, Dinesh Singal, Sunny Srivastava, Julie L. Teel, Jorge L. Castriz, Louis Kantaros, Chandra Venugopal, Cezar Staniloae, Dinesh Gupta, Faizullah Syed, M. Zacharias, Naseem Jaffrani, Phil Wakefield, Mike Nassif, Tariq Haddad, Sherif Iskander, Gregory D. Lewis, Bassam Al‐Joundi, William P. French, Modele O. Ogunniyi, Sitaramesh Emani, Sara Weiss, Richard K. Cheng, Viorel G. Florea, Susan Joseph, Deepak K. Gupta, Samuel Lederman, Joseph L. Izzo, Marc Bernstein(Brigham and Women's Hospital), Erich R. Fruehling, Brian A. Foley, Liwa Younis, David Song(University of Wisconsin–Madison), Vinh Pham, Hai Nguyen(UNSW Sydney), Huan Do(University of Glasgow), Binh Quang Truong, Hien Nguyen, Tuan Anh Nguyen, Hien Nguyen, Dung Thuong Ho
Cited by 44Open Access
Abstract
OBJECTIVE To determine whether the benefits of dapagliflozin in patients with heart failure and reduced ejection fraction (HFrEF) and type 2 diabetes in the Dapagliflozin And Prevention of Adverse-Outcomes in Heart Failure trial (DAPA-HF) varied by background glucose-lowering therapy (GLT). RESEARCH DESIGN AND METHODS We examined the effect of study treatment by the use or not of GLT and by GLT classes and combinations. The primary outcome was a composite of worsening heart failure (hospitalization or urgent visit requiring intravenous therapy) or cardiovascular death. RESULTS In the 2,139 type 2 diabetes patients, the effect of dapagliflozin on the primary outcome was consistent by GLT use or no use (hazard ratio 0.72 [95% CI 0.58–0.88] vs. 0.86 [0.60–1.23]; interaction P = 0.39) and across GLT classes. CONCLUSIONS In DAPA-HF, dapagliflozin improved outcomes irrespective of use or no use of GLT or by GLT type used in patients with type 2 diabetes and HFrEF.
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