FGF/FGFR signaling in health and disease

Yangli Xie(Army Medical University), Nan Su(Army Medical University), Jing Yang(Army Medical University), Qiaoyan Tan(Army Medical University), Shuo Huang(Army Medical University), Min Jin(Army Medical University), Zhenhong Ni(Army Medical University), Bin Zhang(Army Medical University), Dali Zhang(Army Medical University), Fengtao Luo(Army Medical University), Hangang Chen(Army Medical University), Xianding Sun(Army Medical University), Jian Q. Feng(Texas A&M University), Huabing Qi(Army Medical University), Lin Chen(Army Medical University)
Signal Transduction and Targeted Therapy
September 2, 2020
10.1038/s41392-020-00222-7
Cited by 868Open Access
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Abstract

Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple systems.

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