Targeting Piezo1 unleashes innate immunity against cancer and infectious disease
Berk Aykut(New York University), Ruonan Chen(New York University), Jacqueline I. Kim(New York University), Dongling Wu(New York University), Sorin A. A. Shadaloey(New York University), Raquel Abengozar(New York University), Pamela Preiss(New York University), Anjana Saxena(The Graduate Center, CUNY), Smruti Pushalkar(New York University), Joshua Leinwand(New York University), Brian Diskin(New York University), Wei Wang(New York University), Gregor Werba(New York University), Matthew E. Berman(New York University), Steve Ki Buom Lee(New York University), Alireza Khodadadi‐Jamayran, Deepak Saxena(New York University), William A. Coetzee(New York University), George Miller(New York University)
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Abstract
is regulated via up-regulation of histone deacetylase 2. Collectively, our work uncovers Piezo1 as a targetable immune checkpoint that drives immunosuppressive myelopoiesis in cancer and infectious disease.
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