The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1α signalling pathway
Xuping Yang(Sichuan University), Qinhui Liu(Sichuan University), Yanping Li(Sichuan University), Qin Tang(Sichuan University), Tong Wu(Sichuan University), Lei Chen(Sichuan University), Shiyun Pu(Sichuan University), Yingnan Zhao(Sichuan University), Guorong Zhang(Sichuan University), Cuiyuan Huang(Sichuan University), Jinhang Zhang(Sichuan University), Zijing Zhang(Sichuan University), Ya Huang(Sichuan University), Min Zou(Sichuan University), Xiongjie Shi(Wuhan University), Wei Jiang(Sichuan University), Rui Wang(Yangpu Hospital of Tongji University), Jinhan He(Sichuan University)
Cited by 169Open Access
Abstract
study demonstrated that Cana increased AMPK phosphorylation and the expression of Sirt1 and Pgc-1α. The present study reveals a new therapeutic function for Cana in regulating energy homoeostasis. ABBREVIATIONS: , nicotinamide adenine dinucleotide; Dio2, iodothyronine deiodinase 2; Tmem26, transmembrane protein 26; Hoxa9, homeobox A9; FCCP, carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone; Rot/AA, rotenone/antimycin A; OCR, oxygen consumption rate; Pparγ, peroxisome proliferator activated receptor γ; C/ebp, CCAAT/enhancer binding protein; LKB1, liver kinase B1; AUC, area under the cure; Vd, apparent volume of distribution.
Related Papers
No related papers found
Powered by citation graph analysis