EZH2-mediated Epigenetic Silencing of miR-29/miR-30 targets LOXL4 and contributes to Tumorigenesis, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer

Huilong Yin(Air Force Medical University), Yidi Wang(Xijing Hospital), Ye Wu(Air Force Medical University), Xiang Zhang(Air Force Medical University), Xiaofang Zhang(Air Force Medical University), Jun Liu(Air Force Medical University), Ting Wang(Air Force Medical University), Jing Fan(Xijing Hospital), Jianyong Sun(Air Force Medical University), Angang Yang(Air Force Medical University), Rui Zhang(Air Force Medical University)
Theranostics
January 1, 2020
10.7150/thno.44849
Cited by 101Open Access
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Abstract

Our findings identified EZH2-miR-29b/miR-30d-LOXL4 signaling pathway was involved in breast tumorigenesis, and suggested that the epigenetic modulation represents a potential therapeutic target for breast cancer by controlling macrophage activation.

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